cAMP-dependent protein kinase catalytic subunit gamma
Details
- Name
- cAMP-dependent protein kinase catalytic subunit gamma
- Synonyms
- 2.7.11.11
- PKA C-gamma
- Gene Name
- PRKACG
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052669|cAMP-dependent protein kinase catalytic subunit gamma MGNAPAKKDTEQEESVNEFLAKARGDFLYRWGNPAQNTASSDQFERLRTLGMGSFGRVML VRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFPFLVKLQFSFKDNSYLYLV MEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGY LQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFY ADQPIQIYEKIVSGRVRFPSKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFAT TSWIAIYEKKVEAPFIPKYTGPGDASNFDDYEEEELRISINEKCAKEFSEF
- Number of residues
- 351
- Molecular Weight
- 40434.18
- Theoretical pI
- Not Available
- GO Classification
- FunctionsAMP-activated protein kinase activity / ATP binding / cAMP-dependent protein kinase activity / protein kinase A regulatory subunit binding / protein serine kinase activity / protein threonine kinase activityProcessesactivation of protein kinase A activity / adaptive immune response / blood coagulation / cellular response to glucagon stimulus / chemical synaptic transmission / high-density lipoprotein particle assembly / male gonad development / negative regulation of inflammatory response to antigenic stimulus / protein kinase A signaling / renal water homeostasis / spermatogenesis / stimulatory C-type lectin receptor signaling pathwayComponentsciliary base / cytosol / nucleoplasm / nucleus / synapse
- General Function
- Phosphorylates a large number of substrates in the cytoplasm and the nucleus.
- Specific Function
- Amp-activated protein kinase activity
- Pfam Domain Function
- Pkinase (PF00069)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0052670|cAMP-dependent protein kinase catalytic subunit gamma (PRKACG) ATGGGCAACGCCCCCGCCAAGAAGGACACCGAGCAGGAGGAGAGCGTGAACGAGTTCCTA GCCAAAGCCAGAGGAGATTTCCTCTACAGATGGGGAAACCCCGCTCAAAACACCGCCAGC TCGGATCAGTTCGAACGGCTCAGGACGCTGGGCATGGGCTCCTTCGGGCGGGTGATGCTG GTGAGGCACCAGGAGACCGGCGGCCACTACGCCATGAAGATCCTCAACAAGCAGAAGGTG GTGAAGATGAAGCAGGTCGAGCACATACTGAACGAGAAGCGCATCCTGCAGGCGATCGAC TTTCCGTTCCTCGTCAAGCTCCAGTTCTCCTTTAAGGACAACTCCTACCTGTACCTGGTG ATGGAGTACGTGCCGGGTGGGGAGATGTTCTCCCGCCTACAGCGCGTCGGAAGGTTTAGC GAGCCCCATGCCTGTTTCTATGCCGCCCAGGTCGTCCTGGCCGTCCAGTACCTACACTCG CTCGACCTCATCCACCGCGACCTGAAGCCCGAGAATCTCCTCATCGACCAGCAGGGCTAC CTGCAGGTGACGGACTTCGGTTTCGCCAAGCGCGTGAAGGGCCGCACTTGGACCTTGTGC GGGACCCCAGAGTACCTGGCCCCCGAGATCATCCTGAGCAAAGGCTACAACAAGGCCGTG GACTGGTGGGCCCTAGGGGTGCTCATCTATGAGATGGCCGTGGGCTTCCCACCCTTCTAC GCCGACCAGCCCATCCAGATCTACGAGAAGATCGTCTCTGGGAGGGTGCGGTTTCCCTCC AAACTCAGCTCTGACCTCAAGCATCTGCTGCGGAGCCTGCTGCAGGTGGACCTCACCAAG CGCTTCGGAAACCTCAGGAACGGGGTTGGCGACATCAAGAACCACAAGTGGTTCGCCACA ACCAGCTGGATCGCCATCTATGAGAAGAAGGTGGAAGCTCCCTTCATCCCGAAGTACACA GGCCCTGGGGATGCCAGTAACTTTGACGACTACGAGGAGGAAGAGCTCCGGATCTCCATC AATGAGAAGTGTGCCAAGGAGTTTTCTGAGTTTTAG
- Chromosome Location
- 9
- Locus
- 9q21.11
- External Identifiers
Resource Link UniProtKB ID P22612 UniProtKB Entry Name KAPCG_HUMAN HGNC ID HGNC:9382 - General References
- Beebe SJ, Oyen O, Sandberg M, Froysa A, Hansson V, Jahnsen T: Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis--representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase. Mol Endocrinol. 1990 Mar;4(3):465-75. [Article]
- Reinton N, Haugen TB, Orstavik S, Skalhegg BS, Hansson V, Jahnsen T, Tasken K: The gene encoding the C gamma catalytic subunit of cAMP-dependent protein kinase is a transcribed retroposon. Genomics. 1998 Apr 15;49(2):290-7. doi: 10.1006/geno.1998.5240. [Article]
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details