Macrophage mannose receptor 1

Details

Name
Macrophage mannose receptor 1
Synonyms
  • C-type lectin domain family 13 member D
  • C-type lectin domain family 13 member D-like
  • CLEC13D
  • CLEC13DL
  • hMR
  • Human mannose receptor
  • Macrophage mannose receptor 1-like protein 1
  • MMR
  • MRC1L1
Gene Name
MRC1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0051590|Macrophage mannose receptor 1
MRLPLLLVFASVIPGAVLLLDTRQFLIYNEDHKRCVDAVSPSAVQTAACNQDAESQKFRW
VSESQIMSVAFKLCLGVPSKTDWVAITLYACDSKSEFQKWECKNDTLLGIKGEDLFFNYG
NRQEKNIMLYKGSGLWSRWKIYGTTDNLCSRGYEAMYTLLGNANGATCAFPFKFENKWYA
DCTSAGRSDGWLWCGTTTDYDTDKLFGYCPLKFEGSESLWNKDPLTSVSYQINSKSALTW
HQARKSCQQQNAELLSITEIHEQTYLTGLTSSLTSGLWIGLNSLSFNSGWQWSDRSPFRY
LNWLPGSPSAEPGKSCVSLNPGKNAKWENLECVQKLGYICKKGNTTLNSFVIPSESDVPT
HCPSQWWPYAGHCYKIHRDEKKIQRDALTTCRKEGGDLTSIHTIEELDFIISQLGYEPND
ELWIGLNDIKIQMYFEWSDGTPVTFTKWLRGEPSHENNRQEDCVVMKGKDGYWADRGCEW
PLGYICKMKSRSQGPEIVEVEKGCRKGWKKHHFYCYMIGHTLSTFAEANQTCNNENAYLT
TIEDRYEQAFLTSFVGLRPEKYFWTGLSDIQTKGTFQWTIEEEVRFTHWNSDMPGRKPGC
VAMRTGIAGGLWDVLKCDEKAKFVCKHWAEGVTHPPKPTTTPEPKCPEDWGASSRTSLCF
KLYAKGKHEKKTWFESRDFCRALGGDLASINNKEEQQTIWRLITASGSYHKLFWLGLTYG
SPSEGFTWSDGSPVSYENWAYGEPNNYQNVEYCGELKGDPTMSWNDINCEHLNNWICQIQ
KGQTPKPEPTPAPQDNPPVTEDGWVIYKDYQYYFSKEKETMDNARAFCKRNFGDLVSIQS
ESEKKFLWKYVNRNDAQSAYFIGLLISLDKKFAWMDGSKVDYVSWATGEPNFANEDENCV
TMYSNSGFWNDINCGYPNAFICQRHNSSINATTVMPTMPSVPSGCKEGWNFYSNKCFKIF
GFMEEERKNWQEARKACIGFGGNLVSIQNEKEQAFLTYHMKDSTFSAWTGLNDVNSEHTF
LWTDGRGVHYTNWGKGYPGGRRSSLSYEDADCVVIIGGASNEAGKWMDDTCDSKRGYICQ
TRSDPSLTNPPATIQTDGFVKYGKSSYSLMRQKFQWHEAETYCKLHNSLIASILDPYSNA
FAWLQMETSNERVWIALNSNLTDNQYTWTDKWRVRYTNWAADEPKLKSACVYLDLDGYWK
TAHCNESFYFLCKRSDEIPATEPPQLPGRCPESDHTAWIPFHGHCYYIESSYTRNWGQAS
LECLRMGSSLVSIESAAESSFLSYRVEPLKSKTNFWIGLFRNVEGTWLWINNSPVSFVNW
NTGDPSGERNDCVALHASSGFWSNIHCSSYKGYICKRPKIIDAKPTHELLTTKADTRKMD
PSKPSSNVAGVVIIVILLILTGAGLAAYFFYKKRRVHLPQEGAFENTLYFNSQSSPGTSD
MKDLVGNIEQNEHSVI
Number of residues
1456
Molecular Weight
166010.315
Theoretical pI
Not Available
GO Classification
Functions
mannose binding / receptor activity / transmembrane signaling receptor activity / virus receptor activity
Processes
cellular response to interferon-gamma / cellular response to interleukin-4 / cellular response to lipopolysaccharide / receptor-mediated endocytosis
Components
cell surface / endosome membrane / integral component of plasma membrane / plasma membrane
General Function
Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.
Specific Function
Mannose binding
Pfam Domain Function
Transmembrane Regions
1390-1410
Cellular Location
Endosome membrane
Gene sequence
>lcl|BSEQ0051591|Macrophage mannose receptor 1 (MRC1)
ATGAGGCTACCCCTGCTCCTGGTTTTTGCCTCTGTCATTCCGGGTGCTGTTCTCCTACTG
GACACCAGGCAATTTTTAATCTATAATGAAGATCACAAGCGCTGCGTGGATGCAGTGAGT
CCCAGTGCCGTCCAAACCGCAGCTTGCAACCAGGATGCCGAATCACAGAAATTCCGATGG
GTGTCCGAATCTCAGATTATGAGTGTTGCATTTAAATTATGCCTGGGAGTGCCATCAAAA
ACGGACTGGGTTGCTATCACTCTCTATGCCTGTGACTCAAAAAGTGAATTTCAGAAATGG
GAGTGCAAAAATGACACACTTTTGGGGATCAAAGGAGAAGATTTATTTTTTAACTACGGC
AACAGACAAGAAAAGAATATTATGCTCTACAAGGGATCGGGTTTATGGAGCAGGTGGAAG
ATCTATGGAACCACAGACAATCTGTGCTCCAGAGGTTATGAAGCCATGTATACGCTACTA
GGCAATGCCAATGGAGCAACCTGTGCATTCCCGTTCAAGTTTGAAAACAAGTGGTACGCA
GATTGCACGAGTGCTGGGCGGTCGGATGGATGGCTCTGGTGCGGAACCACTACTGACTAT
GACACAGACAAGCTATTTGGATATTGTCCATTGAAATTTGAGGGCAGTGAAAGCTTATGG
AATAAAGACCCGCTGACCAGCGTTTCCTACCAGATAAACTCCAAATCCGCTTTAACGTGG
CACCAGGCGAGGAAAAGCTGCCAACAACAGAACGCTGAGCTCCTGAGCATCACAGAGATT
CATGAGCAAACATACCTGACAGGATTAACCAGTTCCTTGACCTCAGGACTCTGGATTGGA
CTTAACAGTCTGAGCTTCAACAGCGGTTGGCAGTGGAGTGACCGCAGTCCTTTCCGATAT
TTGAACTGGTTACCAGGAAGTCCATCAGCTGAACCTGGAAAAAGCTGTGTGTCACTAAAT
CCTGGAAAAAATGCTAAATGGGAAAATCTGGAATGTGTTCAGAAACTGGGCTATATTTGC
AAAAAGGGCAACACCACTTTAAATTCTTTTGTTATTCCCTCAGAAAGTGATGTGCCTACT
CACTGTCCTAGTCAGTGGTGGCCGTATGCCGGTCACTGTTACAAGATTCACAGAGATGAG
AAAAAAATCCAGAGGGATGCTCTGACCACCTGCAGGAAGGAAGGCGGTGACCTCACAAGT
ATCCACACCATCGAGGAATTGGACTTTATTATCTCCCAGCTAGGATATGAGCCAAATGAC
GAATTGTGGATCGGCTTAAATGACATTAAGATTCAAATGTACTTTGAGTGGAGTGATGGG
ACCCCTGTAACGTTTACCAAATGGCTTCGTGGAGAACCAAGCCATGAAAACAACAGACAG
GAGGATTGTGTGGTGATGAAAGGCAAGGATGGGTACTGGGCAGATCGGGGCTGTGAGTGG
CCTCTTGGCTACATCTGCAAGATGAAATCACGAAGCCAAGGTCCAGAAATAGTGGAAGTC
GAAAAAGGCTGCAGGAAAGGCTGGAAAAAACATCACTTTTACTGCTATATGATTGGACAT
ACGCTTTCAACATTTGCAGAAGCAAACCAAACCTGTAATAATGAGAATGCTTATTTAACA
ACTATTGAAGACAGATATGAACAAGCCTTCCTGACTAGTTTCGTTGGCTTAAGGCCTGAA
AAATATTTCTGGACAGGACTTTCAGATATACAAACCAAAGGGACTTTTCAGTGGACCATC
GAGGAAGAGGTTCGGTTCACCCACTGGAATTCAGATATGCCAGGGCGAAAGCCAGGGTGT
GTTGCCATGAGAACCGGGATTGCAGGGGGCTTATGGGATGTTTTGAAATGTGATGAAAAG
GCAAAATTTGTGTGCAAGCACTGGGCAGAAGGAGTAACCCACCCACCGAAGCCCACGACG
ACTCCCGAACCCAAATGTCCGGAGGATTGGGGCGCCAGCAGTAGAACAAGCTTGTGTTTC
AAGCTGTATGCAAAAGGAAAACATGAGAAGAAAACGTGGTTTGAATCTCGAGATTTTTGT
CGAGCTCTGGGTGGAGACTTAGCTAGCATCAATAACAAAGAGGAACAGCAAACAATATGG
CGATTAATAACAGCTAGTGGAAGCTACCACAAACTGTTTTGGTTGGGATTGACATATGGA
AGCCCTTCAGAAGGTTTTACTTGGAGTGATGGTTCTCCTGTTTCATATGAAAACTGGGCT
TATGGAGAACCTAATAATTATCAAAATGTTGAATACTGTGGTGAGCTGAAAGGTGACCCT
ACTATGTCTTGGAATGATATTAATTGTGAACACCTTAACAACTGGATTTGCCAGATACAA
AAAGGACAAACACCAAAACCTGAGCCAACACCAGCTCCTCAAGACAATCCACCAGTTACT
GAAGATGGGTGGGTTATTTACAAAGACTACCAGTATTATTTCAGCAAAGAGAAGGAAACC
ATGGACAATGCGCGAGCGTTTTGCAAGAGGAATTTTGGTGATCTTGTTTCTATTCAAAGT
GAAAGTGAAAAGAAGTTTCTATGGAAATATGTAAACAGAAATGATGCACAGTCTGCATAT
TTTATTGGTTTATTGATCAGCTTGGATAAAAAGTTTGCTTGGATGGATGGAAGCAAAGTG
GATTACGTGTCTTGGGCCACAGGTGAACCCAATTTTGCAAATGAAGATGAAAACTGTGTG
ACCATGTATTCAAATTCAGGGTTTTGGAATGACATTAACTGTGGCTATCCAAACGCCTTC
ATTTGCCAGCGACATAACAGTAGTATCAATGCTACCACAGTTATGCCTACCATGCCCTCG
GTCCCATCAGGGTGCAAGGAAGGTTGGAATTTCTACAGCAACAAGTGTTTCAAAATCTTT
GGATTTATGGAAGAAGAAAGAAAAAATTGGCAAGAGGCACGAAAAGCTTGTATAGGCTTT
GGAGGGAATCTGGTCTCCATACAAAATGAAAAAGAGCAAGCATTTCTTACCTATCACATG
AAGGACTCCACTTTCAGTGCCTGGACTGGGCTGAATGATGTCAATTCAGAACACACGTTC
CTTTGGACGGATGGACGAGGAGTCCATTACACAAACTGGGGGAAAGGTTACCCTGGTGGA
AGAAGAAGCAGTCTTTCTTATGAAGATGCTGACTGTGTTGTTATTATTGGAGGTGCATCA
AATGAAGCAGGAAAATGGATGGATGATACCTGCGACAGTAAACGAGGCTACATATGCCAG
ACACGATCCGACCCTTCCTTGACTAATCCTCCAGCAACGATTCAAACAGATGGCTTTGTT
AAATATGGCAAAAGCAGCTATTCACTCATGAGACAAAAATTTCAATGGCATGAAGCGGAG
ACATACTGCAAGCTTCACAATTCCCTTATAGCCAGCATTCTGGATCCCTACAGTAATGCA
TTTGCGTGGCTGCAGATGGAAACATCTAATGAACGTGTGTGGATCGCCCTGAACAGTAAC
TTGACTGATAATCAATACACTTGGACTGATAAGTGGAGGGTGAGGTACACTAACTGGGCT
GCTGATGAGCCCAAATTGAAATCAGCATGTGTTTATCTGGATCTTGATGGCTACTGGAAG
ACAGCACATTGCAATGAAAGTTTTTACTTTCTCTGTAAAAGATCAGATGAAATCCCTGCT
ACTGAACCCCCACAACTGCCTGGCAGATGCCCGGAGTCAGATCACACAGCATGGATTCCT
TTCCATGGTCACTGTTACTATATTGAGTCCTCATATACAAGAAACTGGGGCCAAGCTTCT
CTGGAATGTCTTCGAATGGGTTCCTCTCTGGTTTCCATTGAAAGTGCTGCAGAATCCAGT
TTTCTGTCATATCGGGTTGAGCCACTTAAAAGTAAAACCAATTTTTGGATAGGATTGTTC
AGAAATGTTGAAGGGACGTGGCTGTGGATAAATAACAGTCCGGTCTCCTTTGTCAACTGG
AACACAGGAGATCCCTCTGGTGAACGGAATGATTGTGTAGCTTTACATGCGTCTTCTGGG
TTTTGGAGTAATATTCACTGTTCATCCTACAAAGGATATATTTGTAAAAGACCAAAAATT
ATTGATGCTAAACCTACTCATGAATTACTTACAACAAAAGCTGACACAAGGAAGATGGAC
CCTTCTAAACCGTCTTCCAACGTGGCCGGAGTAGTCATCATTGTGATCCTCCTGATTTTA
ACGGGTGCTGGCCTTGCCGCCTATTTCTTTTATAAGAAAAGACGTGTGCACCTACCTCAA
GAGGGCGCCTTTGAAAACACTCTGTATTTTAACAGTCAGTCAAGCCCAGGAACTAGTGAT
ATGAAAGATCTCGTGGGCAATATTGAACAGAATGAACACTCGGTCATCTAG
Chromosome Location
10
Locus
10p12.33
External Identifiers
ResourceLink
UniProtKB IDP22897
UniProtKB Entry NameMRC1_HUMAN
HGNC IDHGNC:7228
General References
  1. Taylor ME, Conary JT, Lennartz MR, Stahl PD, Drickamer K: Primary structure of the mannose receptor contains multiple motifs resembling carbohydrate-recognition domains. J Biol Chem. 1990 Jul 25;265(21):12156-62. [PubMed:2373685]
  2. Ezekowitz RA, Sastry K, Bailly P, Warner A: Molecular characterization of the human macrophage mannose receptor: demonstration of multiple carbohydrate recognition-like domains and phagocytosis of yeasts in Cos-1 cells. J Exp Med. 1990 Dec 1;172(6):1785-94. [PubMed:2258707]
  3. Kim SJ, Ruiz N, Bezouska K, Drickamer K: Organization of the gene encoding the human macrophage mannose receptor (MRC1). Genomics. 1992 Nov;14(3):721-7. [PubMed:1294118]
  4. Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L, Steward CA, Sims SK, Jones MC, Searle S, Scott C, Howe K, Hunt SE, Andrews TD, Gilbert JG, Swarbreck D, Ashurst JL, Taylor A, Battles J, Bird CP, Ainscough R, Almeida JP, Ashwell RI, Ambrose KD, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Bates K, Beasley H, Bray-Allen S, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Cahill P, Camire D, Carter NP, Chapman JC, Clark SY, Clarke G, Clee CM, Clegg S, Corby N, Coulson A, Dhami P, Dutta I, Dunn M, Faulkner L, Frankish A, Frankland JA, Garner P, Garnett J, Gribble S, Griffiths C, Grocock R, Gustafson E, Hammond S, Harley JL, Hart E, Heath PD, Ho TP, Hopkins B, Horne J, Howden PJ, Huckle E, Hynds C, Johnson C, Johnson D, Kana A, Kay M, Kimberley AM, Kershaw JK, Kokkinaki M, Laird GK, Lawlor S, Lee HM, Leongamornlert DA, Laird G, Lloyd C, Lloyd DM, Loveland J, Lovell J, McLaren S, McLay KE, McMurray A, Mashreghi-Mohammadi M, Matthews L, Milne S, Nickerson T, Nguyen M, Overton-Larty E, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter K, Rice CM, Rogosin A, Ross MT, Sarafidou T, Sehra HK, Shownkeen R, Skuce CD, Smith M, Standring L, Sycamore N, Tester J, Thorpe A, Torcasso W, Tracey A, Tromans A, Tsolas J, Wall M, Walsh J, Wang H, Weinstock K, West AP, Willey DL, Whitehead SL, Wilming L, Wray PW, Young L, Chen Y, Lovering RC, Moschonas NK, Siebert R, Fechtel K, Bentley D, Durbin R, Hubbard T, Doucette-Stamm L, Beck S, Smith DR, Rogers J: The DNA sequence and comparative analysis of human chromosome 10. Nature. 2004 May 27;429(6990):375-81. [PubMed:15164054]
  5. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334]
  6. Taylor ME, Bezouska K, Drickamer K: Contribution to ligand binding by multiple carbohydrate-recognition domains in the macrophage mannose receptor. J Biol Chem. 1992 Jan 25;267(3):1719-26. [PubMed:1730714]
  7. Picariello G, Ferranti P, Mamone G, Roepstorff P, Addeo F: Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry. Proteomics. 2008 Sep;8(18):3833-47. doi: 10.1002/pmic.200701057. [PubMed:18780401]
  8. Miller JL, de Wet BJ, Martinez-Pomares L, Radcliffe CM, Dwek RA, Rudd PM, Gordon S: The mannose receptor mediates dengue virus infection of macrophages. PLoS Pathog. 2008 Feb 8;4(2):e17. doi: 10.1371/journal.ppat.0040017. [PubMed:18266465]
  9. Op den Brouw ML, Binda RS, Geijtenbeek TB, Janssen HL, Woltman AM: The mannose receptor acts as hepatitis B virus surface antigen receptor mediating interaction with intrahepatic dendritic cells. Virology. 2009 Oct 10;393(1):84-90. doi: 10.1016/j.virol.2009.07.015. Epub 2009 Aug 15. [PubMed:19683778]
  10. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [PubMed:24275569]
  11. Feinberg H, Park-Snyder S, Kolatkar AR, Heise CT, Taylor ME, Weis WI: Structure of a C-type carbohydrate recognition domain from the macrophage mannose receptor. J Biol Chem. 2000 Jul 14;275(28):21539-48. [PubMed:10779515]
  12. Alter A, de Leseleuc L, Van Thuc N, Thai VH, Huong NT, Ba NN, Cardoso CC, Grant AV, Abel L, Moraes MO, Alcais A, Schurr E: Genetic and functional analysis of common MRC1 exon 7 polymorphisms in leprosy susceptibility. Hum Genet. 2010 Mar;127(3):337-48. doi: 10.1007/s00439-009-0775-x. Epub 2009 Dec 25. [PubMed:20035344]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB09266Technetium Tc-99m tilmanoceptapproved, investigationalyesligandDetails