Macrophage mannose receptor 1
Details
- Name
- Macrophage mannose receptor 1
- Synonyms
- C-type lectin domain family 13 member D
- C-type lectin domain family 13 member D-like
- CLEC13D
- CLEC13DL
- hMR
- Human mannose receptor
- Macrophage mannose receptor 1-like protein 1
- MMR
- MRC1L1
- Gene Name
- MRC1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0051590|Macrophage mannose receptor 1 MRLPLLLVFASVIPGAVLLLDTRQFLIYNEDHKRCVDAVSPSAVQTAACNQDAESQKFRW VSESQIMSVAFKLCLGVPSKTDWVAITLYACDSKSEFQKWECKNDTLLGIKGEDLFFNYG NRQEKNIMLYKGSGLWSRWKIYGTTDNLCSRGYEAMYTLLGNANGATCAFPFKFENKWYA DCTSAGRSDGWLWCGTTTDYDTDKLFGYCPLKFEGSESLWNKDPLTSVSYQINSKSALTW HQARKSCQQQNAELLSITEIHEQTYLTGLTSSLTSGLWIGLNSLSFNSGWQWSDRSPFRY LNWLPGSPSAEPGKSCVSLNPGKNAKWENLECVQKLGYICKKGNTTLNSFVIPSESDVPT HCPSQWWPYAGHCYKIHRDEKKIQRDALTTCRKEGGDLTSIHTIEELDFIISQLGYEPND ELWIGLNDIKIQMYFEWSDGTPVTFTKWLRGEPSHENNRQEDCVVMKGKDGYWADRGCEW PLGYICKMKSRSQGPEIVEVEKGCRKGWKKHHFYCYMIGHTLSTFAEANQTCNNENAYLT TIEDRYEQAFLTSFVGLRPEKYFWTGLSDIQTKGTFQWTIEEEVRFTHWNSDMPGRKPGC VAMRTGIAGGLWDVLKCDEKAKFVCKHWAEGVTHPPKPTTTPEPKCPEDWGASSRTSLCF KLYAKGKHEKKTWFESRDFCRALGGDLASINNKEEQQTIWRLITASGSYHKLFWLGLTYG SPSEGFTWSDGSPVSYENWAYGEPNNYQNVEYCGELKGDPTMSWNDINCEHLNNWICQIQ KGQTPKPEPTPAPQDNPPVTEDGWVIYKDYQYYFSKEKETMDNARAFCKRNFGDLVSIQS ESEKKFLWKYVNRNDAQSAYFIGLLISLDKKFAWMDGSKVDYVSWATGEPNFANEDENCV TMYSNSGFWNDINCGYPNAFICQRHNSSINATTVMPTMPSVPSGCKEGWNFYSNKCFKIF GFMEEERKNWQEARKACIGFGGNLVSIQNEKEQAFLTYHMKDSTFSAWTGLNDVNSEHTF LWTDGRGVHYTNWGKGYPGGRRSSLSYEDADCVVIIGGASNEAGKWMDDTCDSKRGYICQ TRSDPSLTNPPATIQTDGFVKYGKSSYSLMRQKFQWHEAETYCKLHNSLIASILDPYSNA FAWLQMETSNERVWIALNSNLTDNQYTWTDKWRVRYTNWAADEPKLKSACVYLDLDGYWK TAHCNESFYFLCKRSDEIPATEPPQLPGRCPESDHTAWIPFHGHCYYIESSYTRNWGQAS LECLRMGSSLVSIESAAESSFLSYRVEPLKSKTNFWIGLFRNVEGTWLWINNSPVSFVNW NTGDPSGERNDCVALHASSGFWSNIHCSSYKGYICKRPKIIDAKPTHELLTTKADTRKMD PSKPSSNVAGVVIIVILLILTGAGLAAYFFYKKRRVHLPQEGAFENTLYFNSQSSPGTSD MKDLVGNIEQNEHSVI
- Number of residues
- 1456
- Molecular Weight
- 166010.315
- Theoretical pI
- Not Available
- GO Classification
- Functionsmannose binding / receptor activity / transmembrane signaling receptor activity / virus receptor activityProcessescellular response to interferon-gamma / cellular response to interleukin-4 / cellular response to lipopolysaccharide / receptor-mediated endocytosisComponentscell surface / endosome membrane / integral component of plasma membrane / plasma membrane
- General Function
- Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.
- Specific Function
- Mannose binding
- Pfam Domain Function
- Transmembrane Regions
- 1390-1410
- Cellular Location
- Endosome membrane
- Gene sequence
>lcl|BSEQ0051591|Macrophage mannose receptor 1 (MRC1) ATGAGGCTACCCCTGCTCCTGGTTTTTGCCTCTGTCATTCCGGGTGCTGTTCTCCTACTG GACACCAGGCAATTTTTAATCTATAATGAAGATCACAAGCGCTGCGTGGATGCAGTGAGT CCCAGTGCCGTCCAAACCGCAGCTTGCAACCAGGATGCCGAATCACAGAAATTCCGATGG GTGTCCGAATCTCAGATTATGAGTGTTGCATTTAAATTATGCCTGGGAGTGCCATCAAAA ACGGACTGGGTTGCTATCACTCTCTATGCCTGTGACTCAAAAAGTGAATTTCAGAAATGG GAGTGCAAAAATGACACACTTTTGGGGATCAAAGGAGAAGATTTATTTTTTAACTACGGC AACAGACAAGAAAAGAATATTATGCTCTACAAGGGATCGGGTTTATGGAGCAGGTGGAAG ATCTATGGAACCACAGACAATCTGTGCTCCAGAGGTTATGAAGCCATGTATACGCTACTA GGCAATGCCAATGGAGCAACCTGTGCATTCCCGTTCAAGTTTGAAAACAAGTGGTACGCA GATTGCACGAGTGCTGGGCGGTCGGATGGATGGCTCTGGTGCGGAACCACTACTGACTAT GACACAGACAAGCTATTTGGATATTGTCCATTGAAATTTGAGGGCAGTGAAAGCTTATGG AATAAAGACCCGCTGACCAGCGTTTCCTACCAGATAAACTCCAAATCCGCTTTAACGTGG CACCAGGCGAGGAAAAGCTGCCAACAACAGAACGCTGAGCTCCTGAGCATCACAGAGATT CATGAGCAAACATACCTGACAGGATTAACCAGTTCCTTGACCTCAGGACTCTGGATTGGA CTTAACAGTCTGAGCTTCAACAGCGGTTGGCAGTGGAGTGACCGCAGTCCTTTCCGATAT TTGAACTGGTTACCAGGAAGTCCATCAGCTGAACCTGGAAAAAGCTGTGTGTCACTAAAT CCTGGAAAAAATGCTAAATGGGAAAATCTGGAATGTGTTCAGAAACTGGGCTATATTTGC AAAAAGGGCAACACCACTTTAAATTCTTTTGTTATTCCCTCAGAAAGTGATGTGCCTACT CACTGTCCTAGTCAGTGGTGGCCGTATGCCGGTCACTGTTACAAGATTCACAGAGATGAG AAAAAAATCCAGAGGGATGCTCTGACCACCTGCAGGAAGGAAGGCGGTGACCTCACAAGT ATCCACACCATCGAGGAATTGGACTTTATTATCTCCCAGCTAGGATATGAGCCAAATGAC GAATTGTGGATCGGCTTAAATGACATTAAGATTCAAATGTACTTTGAGTGGAGTGATGGG ACCCCTGTAACGTTTACCAAATGGCTTCGTGGAGAACCAAGCCATGAAAACAACAGACAG GAGGATTGTGTGGTGATGAAAGGCAAGGATGGGTACTGGGCAGATCGGGGCTGTGAGTGG CCTCTTGGCTACATCTGCAAGATGAAATCACGAAGCCAAGGTCCAGAAATAGTGGAAGTC GAAAAAGGCTGCAGGAAAGGCTGGAAAAAACATCACTTTTACTGCTATATGATTGGACAT ACGCTTTCAACATTTGCAGAAGCAAACCAAACCTGTAATAATGAGAATGCTTATTTAACA ACTATTGAAGACAGATATGAACAAGCCTTCCTGACTAGTTTCGTTGGCTTAAGGCCTGAA AAATATTTCTGGACAGGACTTTCAGATATACAAACCAAAGGGACTTTTCAGTGGACCATC GAGGAAGAGGTTCGGTTCACCCACTGGAATTCAGATATGCCAGGGCGAAAGCCAGGGTGT GTTGCCATGAGAACCGGGATTGCAGGGGGCTTATGGGATGTTTTGAAATGTGATGAAAAG GCAAAATTTGTGTGCAAGCACTGGGCAGAAGGAGTAACCCACCCACCGAAGCCCACGACG ACTCCCGAACCCAAATGTCCGGAGGATTGGGGCGCCAGCAGTAGAACAAGCTTGTGTTTC AAGCTGTATGCAAAAGGAAAACATGAGAAGAAAACGTGGTTTGAATCTCGAGATTTTTGT CGAGCTCTGGGTGGAGACTTAGCTAGCATCAATAACAAAGAGGAACAGCAAACAATATGG CGATTAATAACAGCTAGTGGAAGCTACCACAAACTGTTTTGGTTGGGATTGACATATGGA AGCCCTTCAGAAGGTTTTACTTGGAGTGATGGTTCTCCTGTTTCATATGAAAACTGGGCT TATGGAGAACCTAATAATTATCAAAATGTTGAATACTGTGGTGAGCTGAAAGGTGACCCT ACTATGTCTTGGAATGATATTAATTGTGAACACCTTAACAACTGGATTTGCCAGATACAA AAAGGACAAACACCAAAACCTGAGCCAACACCAGCTCCTCAAGACAATCCACCAGTTACT GAAGATGGGTGGGTTATTTACAAAGACTACCAGTATTATTTCAGCAAAGAGAAGGAAACC ATGGACAATGCGCGAGCGTTTTGCAAGAGGAATTTTGGTGATCTTGTTTCTATTCAAAGT GAAAGTGAAAAGAAGTTTCTATGGAAATATGTAAACAGAAATGATGCACAGTCTGCATAT TTTATTGGTTTATTGATCAGCTTGGATAAAAAGTTTGCTTGGATGGATGGAAGCAAAGTG GATTACGTGTCTTGGGCCACAGGTGAACCCAATTTTGCAAATGAAGATGAAAACTGTGTG ACCATGTATTCAAATTCAGGGTTTTGGAATGACATTAACTGTGGCTATCCAAACGCCTTC ATTTGCCAGCGACATAACAGTAGTATCAATGCTACCACAGTTATGCCTACCATGCCCTCG GTCCCATCAGGGTGCAAGGAAGGTTGGAATTTCTACAGCAACAAGTGTTTCAAAATCTTT GGATTTATGGAAGAAGAAAGAAAAAATTGGCAAGAGGCACGAAAAGCTTGTATAGGCTTT GGAGGGAATCTGGTCTCCATACAAAATGAAAAAGAGCAAGCATTTCTTACCTATCACATG AAGGACTCCACTTTCAGTGCCTGGACTGGGCTGAATGATGTCAATTCAGAACACACGTTC CTTTGGACGGATGGACGAGGAGTCCATTACACAAACTGGGGGAAAGGTTACCCTGGTGGA AGAAGAAGCAGTCTTTCTTATGAAGATGCTGACTGTGTTGTTATTATTGGAGGTGCATCA AATGAAGCAGGAAAATGGATGGATGATACCTGCGACAGTAAACGAGGCTACATATGCCAG ACACGATCCGACCCTTCCTTGACTAATCCTCCAGCAACGATTCAAACAGATGGCTTTGTT AAATATGGCAAAAGCAGCTATTCACTCATGAGACAAAAATTTCAATGGCATGAAGCGGAG ACATACTGCAAGCTTCACAATTCCCTTATAGCCAGCATTCTGGATCCCTACAGTAATGCA TTTGCGTGGCTGCAGATGGAAACATCTAATGAACGTGTGTGGATCGCCCTGAACAGTAAC TTGACTGATAATCAATACACTTGGACTGATAAGTGGAGGGTGAGGTACACTAACTGGGCT GCTGATGAGCCCAAATTGAAATCAGCATGTGTTTATCTGGATCTTGATGGCTACTGGAAG ACAGCACATTGCAATGAAAGTTTTTACTTTCTCTGTAAAAGATCAGATGAAATCCCTGCT ACTGAACCCCCACAACTGCCTGGCAGATGCCCGGAGTCAGATCACACAGCATGGATTCCT TTCCATGGTCACTGTTACTATATTGAGTCCTCATATACAAGAAACTGGGGCCAAGCTTCT CTGGAATGTCTTCGAATGGGTTCCTCTCTGGTTTCCATTGAAAGTGCTGCAGAATCCAGT TTTCTGTCATATCGGGTTGAGCCACTTAAAAGTAAAACCAATTTTTGGATAGGATTGTTC AGAAATGTTGAAGGGACGTGGCTGTGGATAAATAACAGTCCGGTCTCCTTTGTCAACTGG AACACAGGAGATCCCTCTGGTGAACGGAATGATTGTGTAGCTTTACATGCGTCTTCTGGG TTTTGGAGTAATATTCACTGTTCATCCTACAAAGGATATATTTGTAAAAGACCAAAAATT ATTGATGCTAAACCTACTCATGAATTACTTACAACAAAAGCTGACACAAGGAAGATGGAC CCTTCTAAACCGTCTTCCAACGTGGCCGGAGTAGTCATCATTGTGATCCTCCTGATTTTA ACGGGTGCTGGCCTTGCCGCCTATTTCTTTTATAAGAAAAGACGTGTGCACCTACCTCAA GAGGGCGCCTTTGAAAACACTCTGTATTTTAACAGTCAGTCAAGCCCAGGAACTAGTGAT ATGAAAGATCTCGTGGGCAATATTGAACAGAATGAACACTCGGTCATCTAG
- Chromosome Location
- 10
- Locus
- 10p12.33
- External Identifiers
Resource Link UniProtKB ID P22897 UniProtKB Entry Name MRC1_HUMAN HGNC ID HGNC:7228 - General References
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