60S ribosomal protein L13a

Details

Name
60S ribosomal protein L13a
Synonyms
  • 23 kDa highly basic protein
Gene Name
RPL13A
Organism
Humans
Amino acid sequence
>lcl|BSEQ0012664|60S ribosomal protein L13a
MAEVQVLVLDGRGHLLGRLAAIVAKQVLLGRKVVVVRCEGINISGNFYRNKLKYLAFLRK
RMNTNPSRGPYHFRAPSRIFWRTVRGMLPHKTKRGQAALDRLKVFDGIPPPYDKKKRMVV
PAALKVVRLKPTRKFAYLGRLAHEVGWKYQAVTATLEEKRKEKAKIHYRKKKQLMRLRKQ
AEKNVEKKIDKYTEVLKTHGLLV
Number of residues
203
Molecular Weight
23577.11
Theoretical pI
11.57
GO Classification
Functions
mRNA binding / poly(A) RNA binding / structural constituent of ribosome
Processes
cellular protein metabolic process / cellular response to interferon-gamma / gene expression / negative regulation of formation of translation preinitiation complex / negative regulation of translation / nuclear-transcribed mRNA catabolic process, nonsense-mediated decay / SRP-dependent cotranslational protein targeting to membrane / translation / translational elongation / translational initiation / translational termination / viral life cycle / viral process / viral transcription
Components
cytoplasm / cytosol / cytosolic large ribosomal subunit / focal adhesion / GAIT complex / large ribosomal subunit / membrane / nucleolus / nucleus / ribonucleoprotein complex
General Function
Structural constituent of ribosome
Specific Function
Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. Involved in methylation of rRNA.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0012665|60S ribosomal protein L13a (RPL13A)
ATGAACACCAACCCTTCCCGAGGCCCCTACCACTTCCGGGCCCCCAGCCGCATCTTCTGG
CGGACCGTGCGAGGTATGCTGCCCCACAAAACCAAGCGAGGCCAGGCCGCTCTGGACCGT
CTCAAGGTGTTTGACGGCATCCCACCGCCCTACGACAAGAAAAAGCGGATGGTGGTTCCT
GCTGCCCTCAAGGTCGTGCGTCTGAAGCCTACAAGAAAGTTTGCCTATCTGGGGCGCCTG
GCTCACGAGGTTGGCTGGAAGTACCAGGCAGTGACAGCCACCCTGGAGGAGAAGAGGAAA
GAGAAAGCCAAGATCCACTACCGGAAGAAGAAACAGCTCATGAGGCTACGGAAACAGGCC
GAGAAGAACGTGGAGAAGAAAATTGACAAATACACAGAGGTCCTCAAGACCCACGGACTC
CTGGTCTGA
Chromosome Location
19
Locus
19q13.3
External Identifiers
ResourceLink
UniProtKB IDP40429
UniProtKB Entry NameRL13A_HUMAN
GenBank Protein ID23691
GenBank Gene IDX56932
HGNC IDHGNC:10304
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB07374AnisomycinexperimentalunknownDetails
DB02494Alpha-Hydroxy-Beta-Phenyl-Propionic AcidexperimentalunknownDetails
DB08437PuromycinexperimentalunknownDetails