Parathyroid hormone 2 receptor
Details
- Name
- Parathyroid hormone 2 receptor
- Synonyms
- PTH2 receptor
- PTHR2
- Gene Name
- PTH2R
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0019615|Parathyroid hormone 2 receptor MAGLGASLHVWGWLMLGSCLLARAQLDSDGTITIEEQIVLVLKAKVQCELNITAQLQEGE GNCFPEWDGLICWPRGTVGKISAVPCPPYIYDFNHKGVAFRHCNPNGTWDFMHSLNKTWA NYSDCLRFLQPDISIGKQEFFERLYVMYTVGYSISFGSLAVAILIIGYFRRLHCTRNYIH MHLFVSFMLRATSIFVKDRVVHAHIGVKELESLIMQDDPQNSIEATSVDKSQYIGCKIAV VMFIYFLATNYYWILVEGLYLHNLIFVAFFSDTKYLWGFILIGWGFPAAFVAAWAVARAT LADARCWELSAGDIKWIYQAPILAAIGLNFILFLNTVRVLATKIWETNAVGHDTRKQYRK LAKSTLVLVLVFGVHYIVFVCLPHSFTGLGWEIRMHCELFFNSFQGFFVSIIYCYCNGEV QAEVKKMWSRWNLSVDWKRTPPCGSRRCGSVLTTVTHSTSSQSQVAASTRMVLISGKAAK IASRQPDSHITLPGYVWSNSEQDCLPHSFHEETKEDSGRQGDDILMEKPSRPMESNPDTE GCQGETEDVL
- Number of residues
- 550
- Molecular Weight
- 62235.335
- Theoretical pI
- Not Available
- GO Classification
- Functionsparathyroid hormone receptor activityProcessescell surface receptor signaling pathway / G-protein coupled receptor signaling pathwayComponentsintegral component of plasma membrane / plasma membrane
- General Function
- Parathyroid hormone receptor activity
- Specific Function
- This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor (By similarity).
- Pfam Domain Function
- Transmembrane Regions
- 146-169 177-196 238-260 276-297 317-337 365-383 395-417
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0019616|Parathyroid hormone 2 receptor (PTH2R) ATGCACAGCTTAAATAAAACATGGGCCAATTATTCAGACTGCCTTCGCTTTCTGCAGCCA GATATCAGCATAGGAAAGCAAGAATTCTTTGAACGCCTCTATGTAATGTATACCGTTGGC TACTCCATCTCTTTTGGTTCCTTGGCTGTGGCTATTCTCATCATTGGTTACTTCAGACGA TTGCATTGCACTAGGAACTATATCCACATGCACTTATTTGTGTCTTTCATGCTGAGAGCT ACAAGCATCTTTGTCAAAGACAGAGTAGTCCATGCTCACATAGGAGTAAAGGAGCTGGAG TCCCTAATAATGCAGGATGACCCACAAAATTCCATTGAGGCAACTTCTGTGGACAAATCA CAATATATCGGGTGCAAGATTGCTGTTGTGATGTTTATTTACTTCCTGGCTACAAATTAT TATTGGATCCTGGTGGAAGGTCTCTACCTGCATAATCTCATCTTTGTGGCTTTCTTTTCG GACACCAAATACCTGTGGGGCTTCATCTTGATAGGCTGGGGGTTTCCAGCAGCATTTGTT GCAGCATGGGCTGTGGCACGAGCAACTCTGGCTGATGCGAGGTGCTGGGAACTTAGTGCT GGAGACATCAAGTGGATTTATCAAGCACCGATCTTAGCAGCTATTGGGCTGAATTTTATT CTGTTTCTGAATACGGTTAGAGTTCTAGCTACCAAAATCTGGGAGACCAATGCAGTTGGG CATGACACAAGGAAGCAATACAGGAAACTGGCCAAATCGACACTGGTCCTGGTCCTAGTC TTTGGAGTGCATTACATCGTGTTCGTATGCCTGCCTCACTCCTTCACTGGGCTCGGGTGG GAGATCCGCATGCACTGTGAGCTCTTCTTCAACTCCTTTCAGGGTTTCTTTGTGTCTATC ATCTACTGCTACTGCAATGGAGAGGTTCAGGCAGAGGTGAAGAAGATGTGGAGTCGGTGG AACCTCTCCGTGGACTGGAAAAGGACACCGCCATGTGGCAGCCGCAGATGCGGCTCAGTG CTCACCACCGTGACGCACAGCACCAGCAGCCAGTCACAGGTGGCGGCCAGCACACGCATG GTGCTTATCTCTGGCAAAGCTGCCAAGATCGCCAGCAGACAGCCTGACAGCCACATCACT TTACCTGGCTATGTCTGGAGTAACTCAGAGCAGGACTGCCTGCCACACTCTTTCCACGAG GAGACCAAGGAAGATAGTGGGAGGCAGGGAGATGATATTCTAATGGAGAAGCCTTCCAGG CCTATGGAATCTAACCCAGACACTGAAGGATGCCAAGGAGAAACTGAGGATGTTCTCTGA
- Chromosome Location
- 2
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P49190 UniProtKB Entry Name PTH2R_HUMAN HGNC ID HGNC:9609 - General References
- Usdin TB, Gruber C, Bonner TI: Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor. J Biol Chem. 1995 Jun 30;270(26):15455-8. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Usdin TB, Modi W, Bonner TI: Assignment of the human PTH2 receptor gene (PTHR2) to chromosome 2q33 by fluorescence in situ hybridization. Genomics. 1996 Oct 1;37(1):140-1. [Article]
- John MR, Arai M, Rubin DA, Jonsson KB, Juppner H: Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues. Endocrinology. 2002 Mar;143(3):1047-57. [Article]