ATP-dependent dethiobiotin synthetase BioD
Details
- Name
- ATP-dependent dethiobiotin synthetase BioD
- Synonyms
- 6.3.3.3
- Dethiobiotin synthase
- DTB synthetase
- DTBS
- Gene Name
- bioD
- Organism
- Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
- Amino acid sequence
>lcl|BSEQ0051231|ATP-dependent dethiobiotin synthetase BioD MTILVVTGTGTGVGKTVVCAALASAARQAGIDVAVCKPVQTGTARGDDDLAEVGRLAGVT QLAGLARYPQPMAPAAAAEHAGMALPARDQIVRLIADLDRPGRLTLVEGAGGLLVELAEP GVTLRDVAVDVAAAALVVVTADLGTLNHTKLTLEALAAQQVSCAGLVIGSWPDPPGLVAA SNRSALARIAMVRAALPAGAASLDAGDFAAMSAAAFDRNWVAGLVG
- Number of residues
- 226
- Molecular Weight
- 22455.665
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / dethiobiotin synthase activity / magnesium ion bindingProcessesbiotin biosynthetic processComponentscytosol
- General Function
- Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring.
- Specific Function
- Atp binding
- Pfam Domain Function
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0051232|ATP-dependent dethiobiotin synthetase BioD (bioD) TTGACGATCCTGGTCGTCACCGGGACCGGCACGGGGGTCGGCAAGACGGTCGTCTGCGCG GCGCTGGCGTCGGCCGCACGTCAGGCCGGCATCGACGTGGCGGTGTGCAAGCCCGTTCAG ACCGGCACCGCCCGCGGTGACGACGACCTCGCCGAGGTCGGCCGGTTGGCCGGGGTGACC CAGCTGGCCGGCTTGGCGCGATATCCGCAGCCGATGGCCCCGGCCGCCGCCGCCGAACAC GCCGGGATGGCGTTGCCCGCCCGCGATCAGATCGTGCGGCTGATCGCAGACCTGGACCGT CCCGGGCGGTTGACCCTCGTCGAGGGGGCGGGCGGGCTGCTGGTCGAACTCGCCGAGCCG GGCGTCACGCTGCGCGATGTCGCCGTCGACGTGGCCGCCGCGGCTTTGGTGGTGGTCACC GCGGACCTGGGCACCCTCAACCACACCAAGTTGACGTTGGAAGCGCTTGCTGCACAACAG GTTTCATGTGCAGGGCTGGTGATCGGCAGCTGGCCGGACCCGCCCGGGTTGGTGGCAGCC TCGAATCGGTCCGCGCTGGCGCGCATTGCTATGGTGCGGGCCGCTCTGCCCGCCGGGGCC GCGTCGCTGGATGCCGGGGACTTCGCGGCGATGAGCGCGGCGGCGTTCGACCGCAACTGG GTTGCCGGGCTGGTCGGCTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P9WPQ5 UniProtKB Entry Name BIOD_MYCTU - General References
- Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998 Jun 11;393(6685):537-44. [Article]
- Kelkar DS, Kumar D, Kumar P, Balakrishnan L, Muthusamy B, Yadav AK, Shrivastava P, Marimuthu A, Anand S, Sundaram H, Kingsbury R, Harsha HC, Nair B, Prasad TS, Chauhan DS, Katoch K, Katoch VM, Kumar P, Chaerkady R, Ramachandran S, Dash D, Pandey A: Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry. Mol Cell Proteomics. 2011 Dec;10(12):M111.011627. doi: 10.1074/mcp.M111.011445. Epub 2011 Oct 3. [Article]
- Dey S, Lane JM, Lee RE, Rubin EJ, Sacchettini JC: Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase . Biochemistry. 2010 Aug 10;49(31):6746-60. doi: 10.1021/bi902097j. [Article]