NADH-ubiquinone oxidoreductase chain 3

Details

Name

NADH-ubiquinone oxidoreductase chain 3

Synonyms

• 7.1.1.2
• NADH dehydrogenase subunit 3

Gene Name

ND3

Organism

Fasciola hepatica

Amino acid sequence

>lcl|BSEQ0052097|NADH-ubiquinone oxidoreductase chain 3
MLFFAVLGLLFFLIFFLVLVFHAFLWNLDLGIFSGERSWVSSFECGFLSQRVTENYFSYT
YFILLVFFVVFDLEVSLLLNMPLQGVLYKNFFSYLFFLVLLGIGFLVEVRRGYVRWAY

Number of residues

118

Molecular Weight

14031.585

Theoretical pI

Not Available

GO Classification

Functions

NADH dehydrogenase (ubiquinone) activity

Components

integral component of membrane / mitochondrial membrane / respirasome

General Function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).

Specific Function

Nadh dehydrogenase (ubiquinone) activity

Pfam Domain Function

• Oxidored_q4 (PF00507)

Transmembrane Regions

1-21 59-79 86-106

Cellular Location

Mitochondrion membrane

Chromosome Location

Not Available

Locus

Not Available

External Identifiers

Resource	Link
UniProtKB ID	Q34522
UniProtKB Entry Name	NU3M_FASHE

General References

1. Garey JR, Wolstenholme DR: Platyhelminth mitochondrial DNA: evidence for early evolutionary origin of a tRNA(serAGN) that contains a dihydrouridine arm replacement loop, and of serine-specifying AGA and AGG codons. J Mol Evol. 1989 May;28(5):374-87. [Article]

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB12245	Triclabendazole	approved, investigational	unknown	inhibitor	Details