2-hydroxychromene-2-carboxylate isomerase
Details
- Name
- 2-hydroxychromene-2-carboxylate isomerase
- Synonyms
- 5.99.1.4
- HCCA isomerase
- Gene Name
- nahD
- Organism
- Pseudomonas putida
- Amino acid sequence
>lcl|BSEQ0017213|2-hydroxychromene-2-carboxylate isomerase MIVDFYFDFLSPFSYLANQRLSKLAQDYGLTIRYNAIDLARVKIAIGNVGPSNRDLKVKL DYLKVDLQRWAQLYGIPLVFPANYNSRRMNIGFYYSGAEAQAAAYVNVVFNAVWGEGIAP DLESLPALVSEKLGWDRSAFEHFLSSNAATERYDEQTHAAIERKVFGVPTMFLGDEMWWG NDRLFMLESAMGRLCRQNADLSS
- Number of residues
- 203
- Molecular Weight
- 23061.0
- Theoretical pI
- 5.3
- GO Classification
- Functions2-hydroxychromene-2-carboxylate isomerase activity / protein disulfide oxidoreductase activityProcessesnaphthalene catabolic process
- General Function
- Protein disulfide oxidoreductase activity
- Specific Function
- Involved in the naphthalene catabolic pathway. Catalyzes the reversible glutathione-dependent isomerization of 2-hydroxychromene-2-carboxylate (HCCA) to trans-O-hydroxybenzylidenepyruvate (THBPA).
- Pfam Domain Function
- DSBA (PF01323)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0017214|2-hydroxychromene-2-carboxylate isomerase (nahD) GTGATTGTCGATTTTTATTTCGATTTTTTGAGTCCGTTCTCTTACTTGGCCAATCAGCGC TTGTCAAAGCTTGCGCAAGATTATGGCCTTACCATTCGTTATAACGCGATCGATTTGGCG CGGGTCAAAATAGCCATTGGAAACGTTGGTCCATCCAATCGCGACTTGAAAGTCAAATTG GACTATTTGAAAGTAGATTTGCAACGGTGGGCCCAGCTTTACGGAATACCGCTGGTATTC CCAGCTAACTACAACAGCCGACGGATGAATATTGGGTTTTATTACTCGGGGGCCGAGGCG CAGGCCGCTGCCTATGTGAATGTAGTATTTAATGCGGTTTGGGGAGAAGGCATAGCTCCA GATTTGGAAAGCTTGCCTGCCCTGGTATCTGAAAAGCTAGGCTGGGATCGTAGTGCTTTC GAGCACTTTCTCAGCAGCAATGCCGCAACAGAGAGGTATGACGAGCAGACACATGCCGCC ATCGAGCGCAAGGTGTTCGGTGTGCCAACGATGTTTTTGGGCGATGAAATGTGGTGGGGG AACGACCGTCTATTCATGCTCGAGAGCGCAATGGGGCGCTTGTGCCGGCAAAATGCCGAT TTAAGTAGTTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q51948 UniProtKB Entry Name NAHD_PSEPU GenBank Protein ID 483791 GenBank Gene ID U09057 - General References
- Eaton RW: Organization and evolution of naphthalene catabolic pathways: sequence of the DNA encoding 2-hydroxychromene-2-carboxylate isomerase and trans-o-hydroxybenzylidenepyruvate hydratase-aldolase from the NAH7 plasmid. J Bacteriol. 1994 Dec;176(24):7757-62. [Article]
- Eaton RW, Chapman PJ: Bacterial metabolism of naphthalene: construction and use of recombinant bacteria to study ring cleavage of 1,2-dihydroxynaphthalene and subsequent reactions. J Bacteriol. 1992 Dec;174(23):7542-54. [Article]
- Thompson LC, Ladner JE, Codreanu SG, Harp J, Gilliland GL, Armstrong RN: 2-Hydroxychromene-2-carboxylic acid isomerase: a kappa class glutathione transferase from Pseudomonas putida. Biochemistry. 2007 Jun 12;46(23):6710-22. Epub 2007 May 18. [Article]