2-hydroxychromene-2-carboxylate isomerase

Details

Name
2-hydroxychromene-2-carboxylate isomerase
Synonyms
  • 5.99.1.4
  • HCCA isomerase
Gene Name
nahD
Organism
Pseudomonas putida
Amino acid sequence
>lcl|BSEQ0017213|2-hydroxychromene-2-carboxylate isomerase
MIVDFYFDFLSPFSYLANQRLSKLAQDYGLTIRYNAIDLARVKIAIGNVGPSNRDLKVKL
DYLKVDLQRWAQLYGIPLVFPANYNSRRMNIGFYYSGAEAQAAAYVNVVFNAVWGEGIAP
DLESLPALVSEKLGWDRSAFEHFLSSNAATERYDEQTHAAIERKVFGVPTMFLGDEMWWG
NDRLFMLESAMGRLCRQNADLSS
Number of residues
203
Molecular Weight
23061.0
Theoretical pI
5.3
GO Classification
Functions
2-hydroxychromene-2-carboxylate isomerase activity / protein disulfide oxidoreductase activity
Processes
naphthalene catabolic process
General Function
Protein disulfide oxidoreductase activity
Specific Function
Involved in the naphthalene catabolic pathway. Catalyzes the reversible glutathione-dependent isomerization of 2-hydroxychromene-2-carboxylate (HCCA) to trans-O-hydroxybenzylidenepyruvate (THBPA).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0017214|2-hydroxychromene-2-carboxylate isomerase (nahD)
GTGATTGTCGATTTTTATTTCGATTTTTTGAGTCCGTTCTCTTACTTGGCCAATCAGCGC
TTGTCAAAGCTTGCGCAAGATTATGGCCTTACCATTCGTTATAACGCGATCGATTTGGCG
CGGGTCAAAATAGCCATTGGAAACGTTGGTCCATCCAATCGCGACTTGAAAGTCAAATTG
GACTATTTGAAAGTAGATTTGCAACGGTGGGCCCAGCTTTACGGAATACCGCTGGTATTC
CCAGCTAACTACAACAGCCGACGGATGAATATTGGGTTTTATTACTCGGGGGCCGAGGCG
CAGGCCGCTGCCTATGTGAATGTAGTATTTAATGCGGTTTGGGGAGAAGGCATAGCTCCA
GATTTGGAAAGCTTGCCTGCCCTGGTATCTGAAAAGCTAGGCTGGGATCGTAGTGCTTTC
GAGCACTTTCTCAGCAGCAATGCCGCAACAGAGAGGTATGACGAGCAGACACATGCCGCC
ATCGAGCGCAAGGTGTTCGGTGTGCCAACGATGTTTTTGGGCGATGAAATGTGGTGGGGG
AACGACCGTCTATTCATGCTCGAGAGCGCAATGGGGCGCTTGTGCCGGCAAAATGCCGAT
TTAAGTAGTTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ51948
UniProtKB Entry NameNAHD_PSEPU
GenBank Protein ID483791
GenBank Gene IDU09057
General References
  1. Eaton RW: Organization and evolution of naphthalene catabolic pathways: sequence of the DNA encoding 2-hydroxychromene-2-carboxylate isomerase and trans-o-hydroxybenzylidenepyruvate hydratase-aldolase from the NAH7 plasmid. J Bacteriol. 1994 Dec;176(24):7757-62. [Article]
  2. Eaton RW, Chapman PJ: Bacterial metabolism of naphthalene: construction and use of recombinant bacteria to study ring cleavage of 1,2-dihydroxynaphthalene and subsequent reactions. J Bacteriol. 1992 Dec;174(23):7542-54. [Article]
  3. Thompson LC, Ladner JE, Codreanu SG, Harp J, Gilliland GL, Armstrong RN: 2-Hydroxychromene-2-carboxylic acid isomerase: a kappa class glutathione transferase from Pseudomonas putida. Biochemistry. 2007 Jun 12;46(23):6710-22. Epub 2007 May 18. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB06952(2S)-2-HYDROXY-2H-CHROMENE-2-CARBOXYLIC ACIDexperimentalunknownDetails
DB086362-HydroxybenzalpyruvateexperimentalunknownDetails
DB086374-(2-METHOXYPHENYL)-2-OXOBUT-3-ENOIC ACIDexperimentalunknownDetails