Methionine--tRNA ligase
Details
- Name
- Methionine--tRNA ligase
- Synonyms
- 6.1.1.10
- Methionyl-tRNA synthetase
- MetRS
- metS
- Gene Name
- metG
- Organism
- Staphylococcus aureus (strain MRSA252)
- Amino acid sequence
>lcl|BSEQ0019278|Methionine--tRNA ligase MAKETFYITTPIYYPSGNLHIGHAYSTVAGDVIARYKRMQGYDVRYLTGTDEHGQKIQEK AQKAGKTEIEYLDEMIAGIKQLWAKLEISNDDFIRTTEERHKHVVEQVFERLLKQGDIYL GEYEGWYSVPDETYYTESQLVDPQYENGKIIGGKSPDSGHEVELVKEESYFFNISKYTDR LLEFYDQNPDFIQPPSRKNEMINNFIKPGLADLAVSRTSFNWGVHVPSNPKHVVYVWIDA LVNYISALGYLSDDESLFNKYWPADIHLMAKEIVRFHSIIWPILLMALDLPLPKKVFAHG WILMKDGKMSKSKGNVVDPNILIDRYGLDATRYYLMRELPFGSDGVFTPEAFVERTNFDL ANDLGNLVNRTISMINKYFDGELPAYQGPLHELDEEMEAMALETVKSYTESMESLQFSVA LSTVWKFISRTNKYIDETTPWVLAKDDSQKDMLGNVMAHLVENIRYAAVLLRPFLTHAPK EIFEQLNINNPQFMEFSSLEQYGVLTEPIMVTGQPKPIFPRLDSEAEIAYIKESMQPPAT EEEKEEIPSKPQIDIKDFDKVEIKAATIIDAEHVKKSDKLLKIQVDLDSEQRQIVSGIAK FYTPDDIIGKKVAVVTNLKPAKLMGQKSEGMILSAEKDGVLTLVSLPSAIPNGAVIK
- Number of residues
- 657
- Molecular Weight
- 74896.93
- Theoretical pI
- 4.86
- GO Classification
- FunctionsATP binding / methionine-tRNA ligase activity / tRNA bindingProcessesmethionyl-tRNA aminoacylationComponentscytoplasm
- General Function
- Trna binding
- Specific Function
- Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0019279|Methionine--tRNA ligase (metG) ATGGCTAAAGAAACATTTTATATAACAACCCCAATATACTATCCTAGTGGGAATTTACAT ATAGGACATGCATATTCTACAGTGGCTGGAGATGTTATTGCAAGATATAAGAGAATGCAA GGATATGATGTTCGTTATTTGACTGGAACGGATGAACACGGTCAAAAAATTCAAGAAAAA GCTCAAAAAGCTGGTAAGACAGAAATTGAATATTTGGATGAGATGATTGCTGGAATTAAA CAATTGTGGGCTAAGCTTGAAATTTCAAATGATGATTTTATCAGAACAACTGAAGAACGT CATAAACATGTCGTTGAGCAAGTATTTGAACGTTTATTAAAGCAAGGTGATATCTATTTA GGTGAATATGAAGGTTGGTATTCTGTTCCGGATGAAACATACTATACAGAGTCACAATTA GTAGACCCACAATACGAAAACGGTAAAATTATTGGTGGTAAAAGTCCAGATTCTGGACAT GAAGTTGAACTAGTAAAAGAAGAAAGTTATTTCTTTAATATTAGTAAATATACAGATCGT TTATTAGAGTTCTATGACCAAAATCCAGATTTTATACAACCACCATCAAGAAAAAATGAA ATGATTAACAACTTCATTAAACCAGGACTTGCTGATTTGGCTGTTTCTCGTACATCATTT AACTGGGGTGTCCATGTTCCGTCTAATCCAAAACATGTTGTTTATGTTTGGATTGATGCG TTAGTTAACTATATTTCAGCATTAGGCTATTTATCAGATGATGAGTCACTATTTAACAAA TACTGGCCAGCAGATATTCATTTAATGGCTAAGGAAATTGTGCGATTCCACTCAATTATT TGGCCTATTTTATTGATGGCATTAGACTTACCGTTACCTAAAAAAGTCTTTGCACATGGT TGGATTTTGATGAAAGATGGAAAAATGAGTAAATCTAAAGGTAATGTCGTAGACCCGAAT ATTTTAATTGATCGCTATGGTTTAGATGCCACACGTTATTATCTAATGCGTGAATTACCA TTTGGTTCAGATGGCGTATTTACACCTGAAGCATTTGTTGAGCGTACAAATTTCGATCTA GCAAATGACTTAGGAAACTTAGTAAACCGTACGATTTCTATGATTAATAAGTACTTTGAT GGCGAATTACCAGCGTATCAAGGTCCACTTCATGAATTAGATGAAGAAATGGAAGCTATG GCTTTAGAAACAGTGAAAAGTTATACTGAAAGCATGGAAAGTTTGCAATTTTCTGTGGCA TTATCTACGGTATGGAAGTTTATTAGTAGAACGAATAAGTATATTGACGAAACAACGCCT TGGGTATTAGCTAAGGACGATAGCCAAAAAGATATGTTAGGCAATGTTATGGCTCACTTA GTTGAAAATATTCGTTATGCAGCTGTATTATTGCGTCCATTCTTAACTCATGCGCCGAAA GAGATTTTTGAACAATTGAACATTAACAATCCTCAATTTATGGAATTTAGTAGTTTAGAG CAATATGGTGTGCTTACTGAGCCAATTATGGTTACTGGGCAACCTAAACCTATTTTCCCA AGATTGGATAGCGAAGCGGAAATTGCATATATCAAAGAATCAATGCAACCGCCTGCTACT GAAGAGGAAAAAGAAGAGATTCCTAGCAAACCTCAAATTGATATTAAAGACTTTGATAAA GTTGAAATTAAGGCAGCAACGATTATTGATGCTGAACATGTTAAGAAGTCAGATAAGCTT TTAAAAATTCAAGTAGACTTAGATTCTGAACAAAGACAAATCGTATCAGGAATTGCCAAA TTCTATACACCAGATGATATTATTGGTAAAAAAGTAGCAGTTGTTACTAACTTGAAACCA GCTAAATTAATGGGACAAAAATCTGAAGGTATGATATTATCTGCTGAAAAAGATGGTGTA TTAACCTTAGTAAGTTTACCAAGTGCAATTCCAAATGGTGCAGTGATTAAATAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q6GJI1 UniProtKB Entry Name SYM_STAAR GenBank Gene ID BX571856 - General References
- Holden MT, Feil EJ, Lindsay JA, Peacock SJ, Day NP, Enright MC, Foster TJ, Moore CE, Hurst L, Atkin R, Barron A, Bason N, Bentley SD, Chillingworth C, Chillingworth T, Churcher C, Clark L, Corton C, Cronin A, Doggett J, Dowd L, Feltwell T, Hance Z, Harris B, Hauser H, Holroyd S, Jagels K, James KD, Lennard N, Line A, Mayes R, Moule S, Mungall K, Ormond D, Quail MA, Rabbinowitsch E, Rutherford K, Sanders M, Sharp S, Simmonds M, Stevens K, Whitehead S, Barrell BG, Spratt BG, Parkhill J: Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance. Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9786-91. Epub 2004 Jun 22. [Article]