Phosphoethanolamine/phosphocholine phosphatase
Details
- Name
- Phosphoethanolamine/phosphocholine phosphatase
- Synonyms
- 3.1.3.75
- Gene Name
- PHOSPHO1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0004289|Phosphoethanolamine/phosphocholine phosphatase MSGCFPVSGLRCLSRDGRMAAQGAPRFLLTFDFDETIVDENSDDSIVRAAPGQRLPESLR ATYREGFYNEYMQRVFKYLGEQGVRPRDLSAIYEAIPLSPGMSDLLQFVAKQGACFEVIL ISDANTFGVESSLRAAGHHSLFRRILSNPSGPDARGLLALRPFHTHSCARCPANMCKHKV LSDYLRERAHDGVHFERLFYVGDGANDFCPMGLLAGGDVAFPRRGYPMHRLIQEAQKAEP SSFRASVVPWETAADVRLHLQQVLKSC
- Number of residues
- 267
- Molecular Weight
- 29712.54
- Theoretical pI
- 7.78
- GO Classification
- Functionsmetal ion binding / phosphatase activity / phosphocholine phosphatase activity / phosphoethanolamine phosphatase activity / pyrophosphatase activityProcessesbone mineralization involved in bone maturation / dephosphorylation / endochondral ossification / glycerophospholipid biosynthetic process / phosphatidylcholine biosynthetic process / phosphatidylethanolamine biosynthetic process / phospholipid metabolic process / regulation of bone mineralization / small molecule metabolic processComponentscytosol
- General Function
- Pyrophosphatase activity
- Specific Function
- Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho). Involved in the generation of inorganic phosphate for bone mineralization.
- Pfam Domain Function
- Put_Phosphatase (PF06888)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0020598|Phosphoethanolamine/phosphocholine phosphatase (PHOSPHO1) ATGTGCCAGCGCCTCTGGCCGTGGCCCGCTAACCAGCCTCTCCCGGGCGGGCTCCTGCCG CGCCCCCTCTCGCTTGCCCCCTCCTCCTCCTCCTCCTGCTGCTCTCCCCCCTGCTCCCAG GACGGCAGGATGGCCGCGCAGGGCGCGCCGCGCTTCCTCCTGACCTTCGACTTCGACGAG ACTATCGTGGACGAAAACAGCGACGATTCGATCGTGCGCGCCGCGCCGGGCCAGCGGCTC CCGGAGAGCCTGCGAGCCACCTACCGCGAGGGCTTCTACAACGAGTACATGCAGCGCGTC TTCAAGTACCTGGGCGAGCAGGGCGTGCGGCCGCGGGACCTGAGCGCCATCTACGAAGCC ATCCCTTTGTCGCCAGGCATGAGCGACCTGCTGCAGTTTGTGGCAAAACAGGGCGCCTGC TTCGAGGTGATTCTCATCTCCGATGCCAACACCTTTGGCGTGGAGAGCTCGCTGCGCGCC GCCGGCCACCACAGCCTGTTCCGCCGCATCCTCAGCAACCCGTCGGGGCCGGATGCGCGG GGACTGCTGGCTCTGCGGCCGTTCCACACACACAGCTGCGCGCGCTGCCCCGCCAACATG TGCAAGCACAAGGTGCTCAGCGACTACCTGCGCGAGCGGGCCCACGACGGCGTGCACTTC GAGCGCCTCTTCTACGTGGGCGACGGCGCCAACGACTTCTGCCCCATGGGGCTGCTGGCG GGCGGCGACGTGGCCTTCCCGCGCCGCGGCTACCCCATGCACCGCCTCATTCAGGAGGCC CAGAAGGCCGAGCCCAGCTCGTTCCGCGCCAGCGTGGTGCCCTGGGAAACGGCTGCAGAT GTGCGCCTCCACCTGCAACAGGTGCTGAAGTCGTGCTGA
- Chromosome Location
- 17
- Locus
- 17q21.32
- External Identifiers
Resource Link UniProtKB ID Q8TCT1 UniProtKB Entry Name PHOP1_HUMAN GenBank Protein ID 20196839 GenBank Gene ID AJ457189 GenAtlas ID PHOSPHO1 HGNC ID HGNC:16815 - General References
- Houston B, Paton IR, Burt DW, Farquharson C: Chromosomal localization of the chicken and mammalian orthologues of the orphan phosphatase PHOSPHO1 gene. Anim Genet. 2002 Dec;33(6):451-4. [Article]
- Roberts SJ, Owen HC, Farquharson C: Identification of a novel splice variant of the haloacid dehalogenase: PHOSPHO1. Biochem Biophys Res Commun. 2008 Jul 11;371(4):872-6. doi: 10.1016/j.bbrc.2008.04.163. Epub 2008 May 8. [Article]
- Zody MC, Garber M, Adams DJ, Sharpe T, Harrow J, Lupski JR, Nicholson C, Searle SM, Wilming L, Young SK, Abouelleil A, Allen NR, Bi W, Bloom T, Borowsky ML, Bugalter BE, Butler J, Chang JL, Chen CK, Cook A, Corum B, Cuomo CA, de Jong PJ, DeCaprio D, Dewar K, FitzGerald M, Gilbert J, Gibson R, Gnerre S, Goldstein S, Grafham DV, Grocock R, Hafez N, Hagopian DS, Hart E, Norman CH, Humphray S, Jaffe DB, Jones M, Kamal M, Khodiyar VK, LaButti K, Laird G, Lehoczky J, Liu X, Lokyitsang T, Loveland J, Lui A, Macdonald P, Major JE, Matthews L, Mauceli E, McCarroll SA, Mihalev AH, Mudge J, Nguyen C, Nicol R, O'Leary SB, Osoegawa K, Schwartz DC, Shaw-Smith C, Stankiewicz P, Steward C, Swarbreck D, Venkataraman V, Whittaker CA, Yang X, Zimmer AR, Bradley A, Hubbard T, Birren BW, Rogers J, Lander ES, Nusbaum C: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. Nature. 2006 Apr 20;440(7087):1045-9. [Article]
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- Roberts SJ, Stewart AJ, Sadler PJ, Farquharson C: Human PHOSPHO1 exhibits high specific phosphoethanolamine and phosphocholine phosphatase activities. Biochem J. 2004 Aug 15;382(Pt 1):59-65. [Article]
- Houston B, Stewart AJ, Farquharson C: PHOSPHO1-A novel phosphatase specifically expressed at sites of mineralisation in bone and cartilage. Bone. 2004 Apr;34(4):629-37. [Article]
- Stewart AJ, Schmid R, Blindauer CA, Paisey SJ, Farquharson C: Comparative modelling of human PHOSPHO1 reveals a new group of phosphatases within the haloacid dehalogenase superfamily. Protein Eng. 2003 Dec;16(12):889-95. [Article]
- Roberts SJ, Stewart AJ, Schmid R, Blindauer CA, Bond SR, Sadler PJ, Farquharson C: Probing the substrate specificities of human PHOSPHO1 and PHOSPHO2. Biochim Biophys Acta. 2005 Aug 31;1752(1):73-82. [Article]