Adenylate kinase 8
Details
- Name
- Adenylate kinase 8
- Synonyms
- 2.7.4.3
- AK 8
- ATP-AMP transphosphorylase 8
- C9orf98
- Gene Name
- AK8
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0009457|Adenylate kinase 8 MDATIAPHRIPPEMPQYGEENHIFELMQNMLEQLLIHQPEDPIPFMIQHLHRDNDNVPRI VILGPPASGKTTIAMWLCKHLNSSLLTLENLILNEFSYTATEARRLYLQRKTVPSALLVQ LIQERLAEEDCIKQGWILDGIPETREQALRIQTLGITPRHVIVLSAPDTVLIERNLGKRI DPQTGEIYHTTFDWPPESEIQNRLMVPEDISELETAQKLLEYHRNIVRVIPSYPKILKVI SADQPCVDVFYQALTYVQSNHRTNAPFTPRVLLLGPVGSGKSLQAALLAQKYRLVNVCCG QLLKEAVADRTTFGELIQPFFEKEMAVPDSLLMKVLSQRLDQQDCIQKGWVLHGVPRDLD QAHLLNRLGYNPNRVFFLNVPFDSIMERLTLRRIDPVTGERYHLMYKPPPTMEIQARLLQ NPKDAEEQVKLKMDLFYRNSADLEQLYGSAITLNGDQDPYTVFEYIESGIINPLPKKIP
- Number of residues
- 479
- Molecular Weight
- 54925.01
- Theoretical pI
- Not Available
- GO Classification
- Functionsadenylate kinase activity / ATP binding / cytidylate kinase activity / nucleoside diphosphate kinase activityProcessesnucleobase-containing small molecule interconversion / nucleobase-containing small molecule metabolic process / nucleoside diphosphate phosphorylation / nucleoside triphosphate biosynthetic process / small molecule metabolic process / ventricular system developmentComponentscytosol
- General Function
- Nucleoside diphosphate kinase activity
- Specific Function
- Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity.
- Pfam Domain Function
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0017465|Adenylate kinase 8 (AK8) ATGGACGCCACTATCGCCCCGCACCGTATCCCCCCCGAGATGCCCCAGTACGGGGAGGAG AACCACATCTTCGAGTTGATGCAGAACATGCTGGAGCAACTCCTGATCCACCAGCCCGAA GATCCCATCCCCTTCATGATCCAGCACTTGCATAGAGACAACGACAATGTGCCCAGGATT GTAATATTAGGTCCACCCGCCTCAGGGAAAACAACAATAGCAATGTGGCTCTGCAAACAT CTGAACAGCAGTCTCCTCACCCTGGAGAACCTGATCTTAAATGAGTTTTCCTATACGGCC ACCGAAGCCAGAAGGCTTTATCTGCAAAGGAAGACAGTTCCCAGCGCGCTGCTCGTCCAG CTGATTCAGGAACGCCTGGCTGAAGAGGATTGCATCAAGCAGGGCTGGATTCTGGATGGC ATCCCTGAGACGCGTGAGCAGGCTCTGAGGATCCAGACCCTGGGGATCACACCCAGACAC GTCATTGTGCTGAGTGCTCCAGACACGGTCCTGATCGAGAGAAACTTGGGGAAGAGAATC GACCCTCAAACTGGAGAGATTTATCACACCACCTTTGACTGGCCACCCGAATCTGAAATC CAGAACCGTCTCATGGTGCCAGAGGACATCTCAGAGCTGGAGACGGCTCAGAAACTGCTG GAGTATCATAGGAACATCGTCAGGGTCATTCCCTCCTACCCCAAAATCCTCAAAGTCATC AGTGCTGACCAGCCATGTGTGGACGTCTTCTACCAGGCTCTGACCTATGTCCAAAGCAAC CATCGTACTAATGCCCCGTTCACCCCGAGGGTGCTGCTGCTCGGGCCTGTGGGCAGTGGG AAAAGTCTGCAGGCCGCCCTCCTGGCCCAGAAATACAGGCTTGTCAATGTCTGCTGTGGG CAACTGCTGAAAGAGGCTGTGGCAGATAGGACCACGTTTGGCGAGCTCATCCAGCCCTTC TTTGAAAAGGAGATGGCAGTTCCTGACAGCCTCCTCATGAAGGTGCTGAGCCAGCGCCTG GACCAGCAGGACTGCATCCAGAAAGGCTGGGTGCTACACGGCGTCCCGCGGGACCTCGAC CAGGCACACCTGCTGAACCGCCTGGGCTACAATCCCAACAGGGTGTTTTTCCTGAATGTG CCATTTGATTCCATCATGGAGCGGCTGACTCTGAGAAGAATTGATCCAGTCACTGGGGAA AGGTACCACCTCATGTACAAGCCACCTCCCACCATGGAGATCCAGGCTCGCCTCCTGCAG AACCCAAAGGATGCTGAAGAGCAGGTCAAGCTGAAAATGGACCTGTTCTACAGGAACTCA GCTGACTTGGAGCAGTTGTATGGGTCGGCCATCACCCTCAATGGGGACCAGGACCCATAC ACAGTCTTCGAATACATCGAGAGTGGGATCATTAATCCCCTGCCCAAGAAAATCCCCTGA
- Chromosome Location
- 9
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q96MA6 UniProtKB Entry Name KAD8_HUMAN HGNC ID HGNC:26526 - General References
- Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
- Humphray SJ, Oliver K, Hunt AR, Plumb RW, Loveland JE, Howe KL, Andrews TD, Searle S, Hunt SE, Scott CE, Jones MC, Ainscough R, Almeida JP, Ambrose KD, Ashwell RI, Babbage AK, Babbage S, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beasley H, Beasley O, Bird CP, Bray-Allen S, Brown AJ, Brown JY, Burford D, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Chen Y, Clarke G, Clark SY, Clee CM, Clegg S, Collier RE, Corby N, Crosier M, Cummings AT, Davies J, Dhami P, Dunn M, Dutta I, Dyer LW, Earthrowl ME, Faulkner L, Fleming CJ, Frankish A, Frankland JA, French L, Fricker DG, Garner P, Garnett J, Ghori J, Gilbert JG, Glison C, Grafham DV, Gribble S, Griffiths C, Griffiths-Jones S, Grocock R, Guy J, Hall RE, Hammond S, Harley JL, Harrison ES, Hart EA, Heath PD, Henderson CD, Hopkins BL, Howard PJ, Howden PJ, Huckle E, Johnson C, Johnson D, Joy AA, Kay M, Keenan S, Kershaw JK, Kimberley AM, King A, Knights A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd C, Lloyd DM, Lovell J, Martin S, Mashreghi-Mohammadi M, Matthews L, McLaren S, McLay KE, McMurray A, Milne S, Nickerson T, Nisbett J, Nordsiek G, Pearce AV, Peck AI, Porter KM, Pandian R, Pelan S, Phillimore B, Povey S, Ramsey Y, Rand V, Scharfe M, Sehra HK, Shownkeen R, Sims SK, Skuce CD, Smith M, Steward CA, Swarbreck D, Sycamore N, Tester J, Thorpe A, Tracey A, Tromans A, Thomas DW, Wall M, Wallis JM, West AP, Whitehead SL, Willey DL, Williams SA, Wilming L, Wray PW, Young L, Ashurst JL, Coulson A, Blocker H, Durbin R, Sulston JE, Hubbard T, Jackson MJ, Bentley DR, Beck S, Rogers J, Dunham I: DNA sequence and analysis of human chromosome 9. Nature. 2004 May 27;429(6990):369-74. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Panayiotou C, Solaroli N, Xu Y, Johansson M, Karlsson A: The characterization of human adenylate kinases 7 and 8 demonstrates differences in kinetic parameters and structural organization among the family of adenylate kinase isoenzymes. Biochem J. 2011 Feb 1;433(3):527-34. doi: 10.1042/BJ20101443. [Article]
- Amiri M, Conserva F, Panayiotou C, Karlsson A, Solaroli N: The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase. Int J Biochem Cell Biol. 2013 May;45(5):925-31. doi: 10.1016/j.biocel.2013.02.004. Epub 2013 Feb 14. [Article]