Interstitial collagenase A

Details

Name
Interstitial collagenase A
Synonyms
  • 3.4.24.7
  • Matrix metalloproteinase-1a
  • Mcol-A
  • McolA
  • MMP-1a
Gene Name
Mmp1a
Organism
Mouse
Amino acid sequence
>lcl|BSEQ0052647|Interstitial collagenase A
MPSLPLLLLLWAASSYSFPVFHNGDRQNVETVWKYLENYYNLGKNMQAKNVNGKEMMAEK
LRQMQQLFGLKVTGNSDPETLRAMKKPRCGVPDVAPYAITHNNPRWTKTHLTYSILNYTP
YLPKAVVEDAIARAFRVWSDVTPLTFQRVFEEEGDIVLSFHRGDHGDNNPFDGPNYKLAH
TFQPGPGLGGDVHYDLDETWTNSSENFNLFYVTAHELGHSLGLTHSSDIGALMFPSYTWY
TEDFVLNQDDINRIQDLYGPSPNPIQPTGATTPHPCNGDLTFDAITTFRGEVFFFKGRFY
IRVNRFMPEPELNLIGILWPNLPVKLDAAYEASMIDQVRYFKGSKVWAVQEQSVLRGFPR
DIHSFFGFPSNVTHIDAAVCEEETGKTYFFVDHMYWRYDENTQSMDPGYPRLTAEDFPGI
DDKVDDVFQKGENFYFFHQSVQHRFNLQIRRVDDSRDSSTWFNC
Number of residues
464
Molecular Weight
53487.625
Theoretical pI
Not Available
GO Classification
Functions
metalloendopeptidase activity / serine-type endopeptidase activity / zinc ion binding
Processes
cellular response to alkaloid / cellular response to drug / cellular response to fluid shear stress / cellular response to interleukin-1 / cellular response to iron(III) ion / cellular response to lipopolysaccharide / cellular response to peptide hormone stimulus / cellular response to tumor necrosis factor / cellular response to UV-A / cellular response to vitamin D / collagen catabolic process / extracellular matrix organization / luteinization / luteolysis / positive regulation of fibroblast migration / positive regulation of smooth muscle cell migration / response to inactivity / response to indole-3-methanol / response to mechanical stimulus
Components
cytoplasm / extracellular matrix / extracellular space
General Function
Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X (By similarity). Able to degrade synthetic peptides and type I and II fibrillar collagen.
Specific Function
Metalloendopeptidase activity
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0052648|Interstitial collagenase A (Mmp1a)
ATGCCTAGCCTTCCTTTGCTGTTGCTTCTCTGGGCTGCTAGCTCATACAGTTTCCCTGTG
TTTCACAACGGAGACCGGCAAAATGTGGAGACAGTCTGGAAATACCTGGAAAACTACTAC
AACTTGGGCAAAAACATGCAAGCTAAAAACGTGAATGGCAAGGAGATGATGGCTGAAAAG
CTGAGGCAAATGCAGCAGTTATTTGGGCTGAAAGTGACTGGAAATTCAGATCCTGAAACC
CTGAGAGCTATGAAGAAGCCCAGGTGTGGGGTGCCTGATGTGGCCCCATATGCCATTACT
CACAACAATCCTCGTTGGACCAAAACACATCTGACATACAGCATTTTAAACTACACACCA
TATTTGCCAAAAGCAGTTGTGGAAGATGCCATCGCGAGAGCCTTTAGAGTCTGGAGTGAT
GTGACACCACTTACGTTCCAAAGAGTCTTTGAGGAGGAAGGCGATATTGTGCTCTCCTTC
CACAGAGGAGACCATGGTGACAACAACCCATTTGATGGACCTAACTATAAGCTTGCTCAC
ACTTTCCAGCCAGGCCCAGGTTTGGGGGGTGATGTTCATTATGACCTTGATGAGACGTGG
ACCAACAGCAGTGAAAATTTCAACTTGTTCTATGTTACGGCTCATGAACTGGGTCACTCC
CTTGGGCTCACTCATTCTAGTGATATAGGAGCACTAATGTTCCCCAGTTACACGTGGTAC
ACTGAAGACTTTGTGCTAAACCAGGATGATATTAATCGCATCCAGGACTTATATGGACCT
TCCCCAAATCCCATCCAGCCAACAGGTGCAACAACACCACATCCATGTAATGGTGATCTA
ACCTTTGATGCTATAACTACATTTAGGGGAGAGGTGTTTTTCTTCAAAGGCAGGTTCTAC
ATTCGGGTAAATAGATTCATGCCAGAACCTGAGCTCAATTTAATAGGTATTCTCTGGCCA
AATCTTCCAGTTAAACTTGACGCTGCTTATGAAGCTAGTATGATAGATCAAGTCCGCTAT
TTCAAAGGCAGCAAAGTATGGGCTGTTCAAGAGCAGAGTGTACTGAGAGGATTCCCCAGA
GACATCCACAGTTTCTTTGGCTTCCCTAGCAATGTGACACACATTGATGCTGCTGTTTGT
GAGGAAGAGACTGGAAAAACATACTTCTTTGTTGACCACATGTACTGGAGGTATGATGAA
AATACACAGTCTATGGATCCAGGTTATCCCAGATTAACAGCAGAAGACTTCCCTGGAATT
GATGATAAAGTTGATGATGTTTTCCAAAAAGGAGAAAATTTCTATTTCTTTCACCAATCA
GTTCAACACAGATTTAACCTCCAAATAAGAAGAGTTGATGATTCCCGTGATTCTAGTACA
TGGTTCAACTGCTAA
Chromosome Location
9
Locus
9 A1
External Identifiers
ResourceLink
UniProtKB IDQ9EPL5
UniProtKB Entry NameMMP1A_MOUSE
General References
  1. Balbin M, Fueyo A, Knauper V, Lopez JM, Alvarez J, Sanchez LM, Quesada V, Bordallo J, Murphy G, Lopez-Otin C: Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation. J Biol Chem. 2001 Mar 30;276(13):10253-62. doi: 10.1074/jbc.M009586200. Epub 2000 Dec 11. [Article]
  2. Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler R, Aturaliya RN, Bailey TL, Bansal M, Baxter L, Beisel KW, Bersano T, Bono H, Chalk AM, Chiu KP, Choudhary V, Christoffels A, Clutterbuck DR, Crowe ML, Dalla E, Dalrymple BP, de Bono B, Della Gatta G, di Bernardo D, Down T, Engstrom P, Fagiolini M, Faulkner G, Fletcher CF, Fukushima T, Furuno M, Futaki S, Gariboldi M, Georgii-Hemming P, Gingeras TR, Gojobori T, Green RE, Gustincich S, Harbers M, Hayashi Y, Hensch TK, Hirokawa N, Hill D, Huminiecki L, Iacono M, Ikeo K, Iwama A, Ishikawa T, Jakt M, Kanapin A, Katoh M, Kawasawa Y, Kelso J, Kitamura H, Kitano H, Kollias G, Krishnan SP, Kruger A, Kummerfeld SK, Kurochkin IV, Lareau LF, Lazarevic D, Lipovich L, Liu J, Liuni S, McWilliam S, Madan Babu M, Madera M, Marchionni L, Matsuda H, Matsuzawa S, Miki H, Mignone F, Miyake S, Morris K, Mottagui-Tabar S, Mulder N, Nakano N, Nakauchi H, Ng P, Nilsson R, Nishiguchi S, Nishikawa S, Nori F, Ohara O, Okazaki Y, Orlando V, Pang KC, Pavan WJ, Pavesi G, Pesole G, Petrovsky N, Piazza S, Reed J, Reid JF, Ring BZ, Ringwald M, Rost B, Ruan Y, Salzberg SL, Sandelin A, Schneider C, Schonbach C, Sekiguchi K, Semple CA, Seno S, Sessa L, Sheng Y, Shibata Y, Shimada H, Shimada K, Silva D, Sinclair B, Sperling S, Stupka E, Sugiura K, Sultana R, Takenaka Y, Taki K, Tammoja K, Tan SL, Tang S, Taylor MS, Tegner J, Teichmann SA, Ueda HR, van Nimwegen E, Verardo R, Wei CL, Yagi K, Yamanishi H, Zabarovsky E, Zhu S, Zimmer A, Hide W, Bult C, Grimmond SM, Teasdale RD, Liu ET, Brusic V, Quackenbush J, Wahlestedt C, Mattick JS, Hume DA, Kai C, Sasaki D, Tomaru Y, Fukuda S, Kanamori-Katayama M, Suzuki M, Aoki J, Arakawa T, Iida J, Imamura K, Itoh M, Kato T, Kawaji H, Kawagashira N, Kawashima T, Kojima M, Kondo S, Konno H, Nakano K, Ninomiya N, Nishio T, Okada M, Plessy C, Shibata K, Shiraki T, Suzuki S, Tagami M, Waki K, Watahiki A, Okamura-Oho Y, Suzuki H, Kawai J, Hayashizaki Y: The transcriptional landscape of the mammalian genome. Science. 2005 Sep 2;309(5740):1559-63. [Article]
  3. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails