Thioredoxin reductase 2, mitochondrial
Details
- Name
- Thioredoxin reductase 2, mitochondrial
- Synonyms
- 1.8.1.9
- Thioredoxin reductase TR3
- Trxr2
- Gene Name
- Txnrd2
- Organism
- Mouse
- Amino acid sequence
>lcl|BSEQ0052694|Thioredoxin reductase 2, mitochondrial MVAAMVAALRGPSRRFRPRTRALTRGTRGAASAAGGQQSFDLLVIGGGSGGLACAKEAAQ LGKKVAVADYVEPSPRGTKWGLGGTCVNVGCIPKKLMHQAALLGGMIRDAHHYGWEVAQP VQHNWKTMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIKASFVDEHTVRGVDKGGKATLLS AEHIVIATGGRPRYPTQVKGALEYGITSDDIFWLKESPGKTLVVGASYVALECAGFLTGI GLDTTVMMRSIPLRGFDQQMSSLVTEHMESHGTQFLKGCVPSHIKKLPTNQLQVTWEDHA SGKEDTGTFDTVLWAIGRVPETRTLNLEKAGISTNPKNQKIIVDAQEATSVPHIYAIGDV AEGRPELTPTAIKAGKLLAQRLFGKSSTLMDYSNVPTTVFTPLEYGCVGLSEEEAVALHG QEHVEVYHAYYKPLEFTVADRDASQCYIKMVCMREPPQLVLGLHFLGPNAGEVTQGFALG IKCGASYAQVMQTVGIHPTCSEEVVKLHISKRSGLEPTVTGCUG
- Number of residues
- 524
- Molecular Weight
- 56602.565
- Theoretical pI
- Not Available
- GO Classification
- Functionsflavin adenine dinucleotide binding / protein homodimerization activity / protein-containing complex binding / thioredoxin-disulfide reductase activityProcessescell redox homeostasis / heart development / hemopoiesis / response to oxygen radicalComponentsaxon / cytoplasm / cytosol / dendrite / intracellular membrane-bounded organelle / mitochondrion / neuronal cell body
- General Function
- Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox-regulated cell signaling.
- Specific Function
- Flavin adenine dinucleotide binding
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Mitochondrion
- Gene sequence
>lcl|BSEQ0052695|Thioredoxin reductase 2, mitochondrial (Txnrd2) ATGGCGGCGATGGTGGCGGCGATGGTGGCGGCGCTGCGTGGACCCAGCAGGCGCTTCCGG CCGCGGACACGGGCTCTGACACGCGGGACAAGGGGCGCGGCGAGTGCAGCGGGAGGGCAG CAGAGCTTTGATCTCTTGGTGATCGGTGGGGGATCCGGTGGCCTAGCTTGTGCCAAGGAA GCTGCTCAGCTGGGAAAGAAGGTGGCTGTGGCTGACTATGTGGAACCTTCTCCCCGAGGC ACCAAGTGGGGCCTTGGTGGCACCTGTGTCAACGTGGGTTGCATACCCAAGAAGCTGATG CATCAGGCTGCACTGCTGGGGGGCATGATCAGAGATGCTCACCACTATGGCTGGGAGGTG GCCCAGCCTGTCCAACACAACTGGAAGACAATGGCAGAAGCCGTGCAAAACCATGTGAAA TCCTTGAACTGGGGTCATCGCGTCCAACTGCAGGACAGGAAAGTCAAGTACTTTAACATC AAAGCCAGCTTTGTGGATGAGCACACAGTTCGCGGTGTGGACAAAGGCGGGAAGGCGACT CTGCTTTCAGCTGAGCACATTGTCATTGCTACAGGAGGACGGCCAAGGTACCCCACACAA GTCAAAGGAGCCCTGGAATATGGAATCACAAGTGACGACATCTTCTGGCTGAAGGAGTCC CCTGGGAAAACGTTGGTGGTTGGAGCCAGCTATGTGGCCCTAGAGTGTGCTGGCTTCCTC ACTGGAATTGGACTGGATACCACTGTCATGATGCGCAGCATCCCTCTCCGAGGCTTTGAC CAGCAAATGTCATCTTTGGTCACAGAGCACATGGAGTCTCATGGCACCCAGTTCCTGAAA GGCTGTGTCCCCTCCCACATCAAAAAACTCCCAACTAACCAGCTGCAGGTCACTTGGGAG GATCATGCTTCTGGCAAGGAAGACACAGGCACCTTTGACACTGTCCTGTGGGCCATAGGG CGAGTTCCAGAAACCAGGACTTTGAATCTGGAGAAGGCTGGCATCAGTACCAACCCTAAG AATCAGAAGATTATTGTGGATGCCCAGGAGGCTACCTCTGTTCCCCACATCTATGCCATT GGAGATGTTGCTGAGGGGCGGCCTGAGCTGACGCCCACAGCTATCAAGGCAGGAAAGCTT CTGGCTCAGCGGCTCTTTGGGAAATCCTCAACCTTAATGGATTACAGCAATGTTCCCACA ACTGTCTTTACACCACTGGAGTATGGCTGTGTGGGGCTGTCTGAGGAGGAGGCTGTGGCT CTCCATGGCCAGGAGCATGTAGAGGTTTACCATGCATATTATAAGCCCCTAGAGTTCACG GTGGCGGATAGGGATGCATCACAGTGCTACATAAAGATGGTATGCATGAGGGAGCCCCCA CAACTGGTGCTGGGCCTGCACTTCCTTGGCCCCAACGCTGGAGAAGTCACCCAAGGATTT GCTCTTGGGATCAAGTGTGGGGCTTCATATGCACAGGTGATGCAGACAGTAGGGATCCAT CCCACCTGCTCTGAGGAGGTGGTCAAGCTGCACATCTCCAAGCGCTCCGGCCTGGAGCCT ACTGTGACTGGTTGCTGAGGCTAA
- Chromosome Location
- 16
- Locus
- 16 11.41 cM
- External Identifiers
Resource Link UniProtKB ID Q9JLT4 UniProtKB Entry Name TRXR2_MOUSE - General References
- Miranda-Vizuete A, Damdimopoulos AE, Spyrou G: cDNA cloning, expression and chromosomal localization of the mouse mitochondrial thioredoxin reductase gene(1). Biochim Biophys Acta. 1999 Oct 6;1447(1):113-8. doi: 10.1016/s0167-4781(99)00129-3. [Article]
- Kawai H, Ota T, Suzuki F, Tatsuka M: Molecular cloning of mouse thioredoxin reductases. Gene. 2000 Jan 25;242(1-2):321-30. doi: 10.1016/s0378-1119(99)00498-9. [Article]
- Sun QA, Wu Y, Zappacosta F, Jeang KT, Lee BJ, Hatfield DL, Gladyshev VN: Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases. J Biol Chem. 1999 Aug 27;274(35):24522-30. [Article]
- Miranda-Vizuete A, Spyrou G: Genomic organization and identification of a novel alternative splicing variant of mouse mitochondrial thioredoxin reductase (TrxR2) gene. Mol Cells. 2002 Jun 30;13(3):488-92. [Article]
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- Sun QA, Zappacosta F, Factor VM, Wirth PJ, Hatfield DL, Gladyshev VN: Heterogeneity within animal thioredoxin reductases. Evidence for alternative first exon splicing. J Biol Chem. 2001 Feb 2;276(5):3106-14. Epub 2000 Nov 1. [Article]
- Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP: A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89. doi: 10.1016/j.cell.2010.12.001. [Article]
- Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30. doi: 10.1016/j.molcel.2013.06.001. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details