4-hydroxy-tetrahydrodipicolinate reductase

Details

Name
4-hydroxy-tetrahydrodipicolinate reductase
Synonyms
  • 1.17.1.8
  • HTPA reductase
Gene Name
dapB
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Amino acid sequence
>lcl|BSEQ0011854|4-hydroxy-tetrahydrodipicolinate reductase
MKYGIVGYSGRMGQEIQKVFSEKGHELVLKVDVNGVEELDSPDVVIDFSSPEALPKTVDL
CKKYRAGLVLGTTALKEEHLQMLRELSKEVPVVQAYNFSIGINVLKRFLSELVKVLEDWD
VEIVETHHRFKKDAPSGTAILLESALGKSVPIHSLRVGGVPGDHVVVFGNIGETIEIKHR
AISRTVFAIGALKAAEFLVGKDPGMYSFEEVIFGGE
Number of residues
216
Molecular Weight
23731.295
Theoretical pI
5.9
GO Classification
Functions
4-hydroxy-tetrahydrodipicolinate reductase / NAD binding / NADP binding / oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor
Processes
diaminopimelate biosynthetic process / lysine biosynthetic process via diaminopimelate
Components
cytoplasm
General Function
Oxidoreductase activity, acting on ch or ch2 groups, nad or nadp as acceptor
Specific Function
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (Probable). Uses NADPH as a reductant with much more efficiency than NADH.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0011855|4-hydroxy-tetrahydrodipicolinate reductase (dapB)
ATGAAGTACGGAATAGTCGGTTATTCCGGAAGGATGGGCCAGGAGATCCAGAAGGTCTTC
TCGGAGAAAGGGCATGAACTCGTTTTGAAGGTGGATGTGAACGGTGTCGAGGAGCTGGAT
TCTCCGGATGTTGTGATCGACTTTTCTTCACCTGAAGCGCTTCCGAAAACGGTGGATCTG
TGTAAAAAATACAGGGCTGGCCTCGTTCTGGGAACAACTGCCCTGAAAGAAGAACATCTC
CAGATGTTGAGGGAGCTTTCGAAAGAAGTACCCGTTGTTCAGGCTTACAACTTCTCCATT
GGCATAAACGTTCTGAAGAGGTTCCTCTCGGAACTCGTCAAAGTCCTCGAAGATTGGGAT
GTTGAGATCGTGGAGACGCACCACCGCTTCAAAAAGGACGCACCCTCCGGAACCGCGATT
CTTCTGGAGAGCGCACTGGGAAAGAGTGTTCCCATTCACTCGCTGAGAGTGGGTGGTGTT
CCGGGAGATCACGTGGTCGTTTTTGGAAACATAGGTGAGACGATCGAGATAAAGCACAGG
GCGATTTCGAGGACTGTTTTCGCCATAGGAGCCCTGAAAGCGGCGGAGTTTCTTGTGGGA
AAAGATCCCGGTATGTACAGTTTCGAAGAAGTGATCTTTGGAGGTGAGTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ9X1K8
UniProtKB Entry NameDAPB_THEMA
GenBank Gene IDAE000512
General References
  1. Nelson KE, Clayton RA, Gill SR, Gwinn ML, Dodson RJ, Haft DH, Hickey EK, Peterson JD, Nelson WC, Ketchum KA, McDonald L, Utterback TR, Malek JA, Linher KD, Garrett MM, Stewart AM, Cotton MD, Pratt MS, Phillips CA, Richardson D, Heidelberg J, Sutton GG, Fleischmann RD, Eisen JA, White O, Salzberg SL, Smith HO, Venter JC, Fraser CM: Evidence for lateral gene transfer between Archaea and bacteria from genome sequence of Thermotoga maritima. Nature. 1999 May 27;399(6734):323-9. [Article]
  2. Pearce FG, Sprissler C, Gerrard JA: Characterization of dihydrodipicolinate reductase from Thermotoga maritima reveals evolution of substrate binding kinetics. J Biochem. 2008 May;143(5):617-23. doi: 10.1093/jb/mvn012. Epub 2008 Feb 4. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails