4-hydroxy-tetrahydrodipicolinate reductase
Details
- Name
- 4-hydroxy-tetrahydrodipicolinate reductase
- Synonyms
- 1.17.1.8
- HTPA reductase
- Gene Name
- dapB
- Organism
- Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
- Amino acid sequence
>lcl|BSEQ0011854|4-hydroxy-tetrahydrodipicolinate reductase MKYGIVGYSGRMGQEIQKVFSEKGHELVLKVDVNGVEELDSPDVVIDFSSPEALPKTVDL CKKYRAGLVLGTTALKEEHLQMLRELSKEVPVVQAYNFSIGINVLKRFLSELVKVLEDWD VEIVETHHRFKKDAPSGTAILLESALGKSVPIHSLRVGGVPGDHVVVFGNIGETIEIKHR AISRTVFAIGALKAAEFLVGKDPGMYSFEEVIFGGE
- Number of residues
- 216
- Molecular Weight
- 23731.295
- Theoretical pI
- 5.9
- GO Classification
- Functions4-hydroxy-tetrahydrodipicolinate reductase / NAD binding / NADP binding / oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptorProcessesdiaminopimelate biosynthetic process / lysine biosynthetic process via diaminopimelateComponentscytoplasm
- General Function
- Oxidoreductase activity, acting on ch or ch2 groups, nad or nadp as acceptor
- Specific Function
- Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (Probable). Uses NADPH as a reductant with much more efficiency than NADH.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0011855|4-hydroxy-tetrahydrodipicolinate reductase (dapB) ATGAAGTACGGAATAGTCGGTTATTCCGGAAGGATGGGCCAGGAGATCCAGAAGGTCTTC TCGGAGAAAGGGCATGAACTCGTTTTGAAGGTGGATGTGAACGGTGTCGAGGAGCTGGAT TCTCCGGATGTTGTGATCGACTTTTCTTCACCTGAAGCGCTTCCGAAAACGGTGGATCTG TGTAAAAAATACAGGGCTGGCCTCGTTCTGGGAACAACTGCCCTGAAAGAAGAACATCTC CAGATGTTGAGGGAGCTTTCGAAAGAAGTACCCGTTGTTCAGGCTTACAACTTCTCCATT GGCATAAACGTTCTGAAGAGGTTCCTCTCGGAACTCGTCAAAGTCCTCGAAGATTGGGAT GTTGAGATCGTGGAGACGCACCACCGCTTCAAAAAGGACGCACCCTCCGGAACCGCGATT CTTCTGGAGAGCGCACTGGGAAAGAGTGTTCCCATTCACTCGCTGAGAGTGGGTGGTGTT CCGGGAGATCACGTGGTCGTTTTTGGAAACATAGGTGAGACGATCGAGATAAAGCACAGG GCGATTTCGAGGACTGTTTTCGCCATAGGAGCCCTGAAAGCGGCGGAGTTTCTTGTGGGA AAAGATCCCGGTATGTACAGTTTCGAAGAAGTGATCTTTGGAGGTGAGTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9X1K8 UniProtKB Entry Name DAPB_THEMA GenBank Gene ID AE000512 - General References
- Nelson KE, Clayton RA, Gill SR, Gwinn ML, Dodson RJ, Haft DH, Hickey EK, Peterson JD, Nelson WC, Ketchum KA, McDonald L, Utterback TR, Malek JA, Linher KD, Garrett MM, Stewart AM, Cotton MD, Pratt MS, Phillips CA, Richardson D, Heidelberg J, Sutton GG, Fleischmann RD, Eisen JA, White O, Salzberg SL, Smith HO, Venter JC, Fraser CM: Evidence for lateral gene transfer between Archaea and bacteria from genome sequence of Thermotoga maritima. Nature. 1999 May 27;399(6734):323-9. [Article]
- Pearce FG, Sprissler C, Gerrard JA: Characterization of dihydrodipicolinate reductase from Thermotoga maritima reveals evolution of substrate binding kinetics. J Biochem. 2008 May;143(5):617-23. doi: 10.1093/jb/mvn012. Epub 2008 Feb 4. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details