4-hydroxy-tetrahydrodipicolinate synthase
Details
- Name
- 4-hydroxy-tetrahydrodipicolinate synthase
- Synonyms
- 4.3.3.7
- HTPA synthase
- Gene Name
- dapA
- Organism
- Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
- Amino acid sequence
>lcl|BSEQ0016438|4-hydroxy-tetrahydrodipicolinate synthase MFRGVGTAIVTPFKNGELDLESYERLVRYQLENGVNALIVLGTTGESPTVNEDEREKLVS RTLEIVDGKIPVIVGAGTNSTEKTLKLVKQAEKLGANGVLVVTPYYNKPTQEGLYQHYKY ISERTDLGIVVYNVPGRTGVNVLPETAARIAADLKNVVGIKEANPDIDQIDRTVSLTKQA RSDFMVWSGNDDRTFYLLCAGGDGVISVVSNVAPKQMVELCAEYFSGNLEKSREVHRKLR PLMKALFVETNPIPVKAALNLMGFIENELRLPLVPASEKTVELLRNVLKESGLL
- Number of residues
- 294
- Molecular Weight
- 32390.055
- Theoretical pI
- 5.96
- GO Classification
- Functions4-hydroxy-tetrahydrodipicolinate synthaseProcessesdiaminopimelate biosynthetic process / lysine biosynthetic process via diaminopimelateComponentscytoplasm
- General Function
- 4-hydroxy-tetrahydrodipicolinate synthase
- Specific Function
- Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
- Pfam Domain Function
- DHDPS (PF00701)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0016439|4-hydroxy-tetrahydrodipicolinate synthase (dapA) ATGTTCAGAGGAGTAGGAACTGCTATCGTTACACCATTCAAAAATGGTGAGCTTGATCTT GAGTCTTACGAGAGGCTTGTCAGGTATCAGCTCGAAAACGGCGTCAACGCGTTGATCGTC CTTGGAACGACAGGTGAATCACCAACCGTCAACGAAGACGAGAGAGAAAAGCTCGTTTCC AGAACTCTCGAGATCGTCGATGGGAAAATCCCTGTGATCGTGGGAGCGGGAACGAATTCC ACCGAAAAAACGCTGAAACTCGTCAAGCAGGCGGAAAAACTCGGAGCGAACGGAGTTCTT GTGGTCACCCCGTATTACAACAAGCCCACACAGGAAGGACTCTATCAGCACTACAAGTAC ATCTCTGAGAGAACGGATCTCGGGATCGTTGTTTACAACGTGCCCGGAAGAACCGGTGTG AACGTTCTCCCGGAAACTGCTGCAAGGATCGCTGCGGACCTCAAGAACGTGGTGGGAATA AAAGAGGCGAACCCGGATATAGACCAGATAGACAGGACGGTATCACTGACAAAACAGGCA AGAAGCGATTTCATGGTGTGGTCCGGCAACGATGATAGAACGTTCTATCTCCTCTGCGCG GGTGGAGACGGCGTCATCTCTGTTGTGTCGAACGTGGCACCGAAACAGATGGTAGAACTC TGCGCAGAGTACTTCAGCGGAAACCTCGAAAAATCGAGGGAGGTTCACAGAAAACTCAGA CCTCTCATGAAGGCACTGTTCGTGGAAACAAATCCGATACCAGTTAAAGCCGCTTTGAAT CTCATGGGATTCATCGAGAACGAGCTGAGACTACCGCTTGTACCTGCCAGTGAAAAGACG GTGGAACTTCTCAGAAACGTTCTCAAGGAGAGTGGATTGCTATGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9X1K9 UniProtKB Entry Name DAPA_THEMA GenBank Protein ID 4982086 GenBank Gene ID AE000512 - General References
- Nelson KE, Clayton RA, Gill SR, Gwinn ML, Dodson RJ, Haft DH, Hickey EK, Peterson JD, Nelson WC, Ketchum KA, McDonald L, Utterback TR, Malek JA, Linher KD, Garrett MM, Stewart AM, Cotton MD, Pratt MS, Phillips CA, Richardson D, Heidelberg J, Sutton GG, Fleischmann RD, Eisen JA, White O, Salzberg SL, Smith HO, Venter JC, Fraser CM: Evidence for lateral gene transfer between Archaea and bacteria from genome sequence of Thermotoga maritima. Nature. 1999 May 27;399(6734):323-9. [Article]
- Pearce FG, Perugini MA, McKerchar HJ, Gerrard JA: Dihydrodipicolinate synthase from Thermotoga maritima. Biochem J. 2006 Dec 1;400(2):359-66. [Article]
- Pearce FG, Dobson RC, Jameson GB, Perugini MA, Gerrard JA: Characterization of monomeric dihydrodipicolinate synthase variant reveals the importance of substrate binding in optimizing oligomerization. Biochim Biophys Acta. 2011 Dec;1814(12):1900-9. doi: 10.1016/j.bbapap.2011.07.016. Epub 2011 Jul 22. [Article]