Reaction: Thalidomide to 1 product
- Reaction
- Reaction type
- Amide Hydrolysis
- Direction
- Major circulating metabolite?
- Yes
- Spontaneous?
- Yes
- Activity
- unknown
- References
- Reist M, Carrupt PA, Francotte E, Testa B: Chiral inversion and hydrolysis of thalidomide: mechanisms and catalysis by bases and serum albumin, and chiral stability of teratogenic metabolites. Chem Res Toxicol. 1998 Dec;11(12):1521-8. [Article]
- Lepper ER, Smith NF, Cox MC, Scripture CD, Figg WD: Thalidomide metabolism and hydrolysis: mechanisms and implications. Curr Drug Metab. 2006 Aug;7(6):677-85. doi: 10.2174/138920006778017777. [Article]
- Comments
- Not Available
- Enzymes
- Not Available