Reaction: Vorapaxar to 1 product
- Reaction
- Reaction type
- hydoxylation
- Direction
- Major circulating metabolite?
- Yes
- Spontaneous?
- No
- Activity
- unknown
- References
- Ghosal A, Lu X, Penner N, Gao L, Ramanathan R, Chowdhury SK, Kishnani NS, Alton KB: Identification of human liver cytochrome P450 enzymes involved in the metabolism of SCH 530348 (Vorapaxar), a potent oral thrombin protease-activated receptor 1 antagonist. Drug Metab Dispos. 2011 Jan;39(1):30-8. doi: 10.1124/dmd.110.035493. Epub 2010 Oct 6. [Article]
- Comments
- Not Available
- Enzymes
Enzyme Km Vmax Role Cytochrome P450 3A4 Not Available Not Available confirmed Cytochrome P450 2J2 Not Available Not Available confirmed