Reaction: (R)-Fluoxetine to 2 products

Reaction
Reaction type
O-dealkylation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Brown CM, Reisfeld B, Mayeno AN: Cytochromes P450: a structure-based summary of biotransformations using representative substrates. Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742 . [PubMed:18259985]
  2. Ring BJ, Eckstein JA, Gillespie JS, Binkley SN, VandenBranden M, Wrighton SA: Identification of the human cytochromes p450 responsible for in vitro formation of R- and S-norfluoxetine. J Pharmacol Exp Ther. 2001 Jun;297(3):1044-50. [PubMed:11356927]
  3. Margolis JM, O'Donnell JP, Mankowski DC, Ekins S, Obach RS: (R)-, (S)-, and racemic fluoxetine N-demethylation by human cytochrome P450 enzymes. Drug Metab Dispos. 2000 Oct;28(10):1187-91. [PubMed:10997938]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 2D6Not AvailableNot Availableimplied