Reaction: hydroxilated form of dolutegravir (M3) to 2 products

Reaction
hydroxilated form of dolutegravir (M3)
DBMET01872
2,4- difluorobenzaldehyde (M5 dolutegravir)
DBMET03561
hydrolized form of dolutegravir (M1)
DBMET01873
Reaction type
hydrolysis
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
active
References
  1. Castellino S, Moss L, Wagner D, Borland J, Song I, Chen S, Lou Y, Min SS, Goljer I, Culp A, Piscitelli SC, Savina PM: Metabolism, excretion, and mass balance of the HIV-1 integrase inhibitor dolutegravir in humans. Antimicrob Agents Chemother. 2013 Aug;57(8):3536-46. doi: 10.1128/AAC.00292-13. Epub 2013 May 13. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 1A1Not AvailableNot Availableconfirmed
Cytochrome P450 1B1Not AvailableNot Availableconfirmed