Reaction: Lonafarnib to 1 product

Reaction
Lonafarnib
DB06448
    Lonafarnib metabolite M1
    DBMET03217
    Reaction type
    oxidation
    Direction
    Major circulating metabolite?
    No
    Spontaneous?
    No
    Activity
    unknown
    References
    1. Ghosal A, Chowdhury SK, Tong W, Hapangama N, Yuan Y, Su AD, Zbaida S: Identification of human liver cytochrome P450 enzymes responsible for the metabolism of lonafarnib (Sarasar). Drug Metab Dispos. 2006 Apr;34(4):628-35. doi: 10.1124/dmd.105.007906. Epub 2006 Jan 27. [Article]
    2. Tong W, Chowdhury SK, Su AD, Feng W, Ghosal A, Alton KB: Identification of unstable metabolites of Lonafarnib using liquid chromatography-quadrupole time-of-flight mass spectrometry, stable isotope incorporation and ion source temperature alteration. J Mass Spectrom. 2006 Nov;41(11):1430-41. doi: 10.1002/jms.1114. [Article]
    Comments
    Not Available
    Enzymes
    Not Available