Reaction: Fexinidazole to 1 product
- Reaction
- Reaction type
- oxidation
- Direction
- Major circulating metabolite?
- No
- Spontaneous?
- No
- Activity
- active
- References
- Torreele E, Bourdin Trunz B, Tweats D, Kaiser M, Brun R, Mazue G, Bray MA, Pecoul B: Fexinidazole--a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness. PLoS Negl Trop Dis. 2010 Dec 21;4(12):e923. doi: 10.1371/journal.pntd.0000923. [Article]
- Tarral A, Blesson S, Mordt OV, Torreele E, Sassella D, Bray MA, Hovsepian L, Evene E, Gualano V, Felices M, Strub-Wourgaft N: Determination of an optimal dosing regimen for fexinidazole, a novel oral drug for the treatment of human African trypanosomiasis: first-in-human studies. Clin Pharmacokinet. 2014 Jun;53(6):565-80. doi: 10.1007/s40262-014-0136-3. [Article]
- FDA Approved Drug Products: Fexinidazole tablets for oral use [Link]
- Comments
- Not Available
- Enzymes
Enzyme Km Vmax Role Cytochrome P450 1A2 Not Available Not Available implied Cytochrome P450 2B6 Not Available Not Available implied Cytochrome P450 2C19 Not Available Not Available implied Cytochrome P450 3A4 Not Available Not Available implied Cytochrome P450 3A5 Not Available Not Available implied Dimethylaniline monooxygenase [N-oxide-forming] 3 Not Available Not Available implied Cytochrome P450 2D6 Not Available Not Available implied
