Reaction: Erdafitinib to 1 product

Reaction
Erdafitinib
DB12147
    M8 Erdafitinib
    DBMET03650
    Reaction type
    N-dealkylation
    Direction
    Major circulating metabolite?
    No
    Spontaneous?
    No
    Activity
    unknown
    References
    1. Scheers E, Borgmans C, Keung C, Bohets H, Wynant I, Poggesi I, Cuyckens F, Leclercq L, Mamidi RNVS: Metabolism and disposition in rats, dogs, and humans of erdafitinib, an orally administered potent pan-fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor. Xenobiotica. 2021 Feb;51(2):177-193. doi: 10.1080/00498254.2020.1821123. Epub 2020 Sep 20. [Article]
    Comments
    Not Available
    Enzymes
    Not Available