Reaction: Oxaliplatin to 1 product

Reaction
Oxaliplatin
DB00526
    Monochloro DACH platinum
    DBMET03682
    Reaction type
    Chlorination
    Direction
    Major circulating metabolite?
    No
    Spontaneous?
    No
    Activity
    unknown
    References
    1. Panczyk M: Pharmacogenetics research on chemotherapy resistance in colorectal cancer over the last 20 years. World J Gastroenterol. 2014 Aug 7;20(29):9775-827. doi: 10.3748/wjg.v20.i29.9775. [Article]
    2. Jerremalm E, Wallin I, Ehrsson H: New insights into the biotransformation and pharmacokinetics of oxaliplatin. J Pharm Sci. 2009 Nov;98(11):3879-85. doi: 10.1002/jps.21732. [Article]
    3. Di Francesco AM, Ruggiero A, Riccardi R: Cellular and molecular aspects of drugs of the future: oxaliplatin. Cell Mol Life Sci. 2002 Nov;59(11):1914-27. doi: 10.1007/pl00012514. [Article]
    4. Wang And X, Guo Z: The role of sulfur in platinum anticancer chemotherapy. Anticancer Agents Med Chem. 2007 Jan;7(1):19-34. doi: 10.2174/187152007779314062. [Article]
    Comments
    Not Available
    Enzymes
    Not Available