Reaction: Iloprost to 1 product

Reaction
Iloprost
DB01088
    Dinor-iloprost
    DBMET03767
    Reaction type
    oxidation
    Direction
    Major circulating metabolite?
    No
    Spontaneous?
    No
    Activity
    inactive
    References
    1. Schermuly RT, Schulz A, Ghofrani HA, Meidow A, Rose F, Roehl A, Weissmann N, Hildebrand M, Kurz J, Grimminger F, Walmrath D, Seeger W: Pharmacokinetics and metabolism of infused versus inhaled iloprost in isolated rabbit lungs. J Pharmacol Exp Ther. 2002 Nov;303(2):741-5. doi: 10.1124/jpet.303.2.741. [Article]
    2. Grant SM, Goa KL: Iloprost. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in peripheral vascular disease, myocardial ischaemia and extracorporeal circulation procedures. Drugs. 1992 Jun;43(6):889-924. doi: 10.2165/00003495-199243060-00008. [Article]
    3. FDA Approved Drug Products: VENTAVIS (iloprost) inhalation solution, for oral inhalation use (March 2022) [Link]
    Comments
    Not Available
    Enzymes
    Not Available