Azelastine hydrochlorideProduct ingredient for Azelastine
- Name
- Azelastine hydrochloride
- Drug Entry
- Azelastine
Azelastine, a phthalazine derivative, is an antihistamine available as an intranasal spray for the treatment of allergic and vasomotor rhinitis and as an ophthalmic solution for the treatment of allergic conjunctivitis.10,11 It is a racemic mixture, though there is no noted difference in pharmacologic activity between enantiomers, and was first granted FDA approval in 1996.10,11 Azelastine is also available in combination with fluticasone propionate as a nasal spray marketed under the trade name Dymista™, which is indicated for the symptomatic treatment of seasonal allergic rhinitis in patients 6 years of age and older.13
- Accession Number
- DBSALT000013
- Structure
- Synonyms
- Azelastine HCl
- UNII
- 0L591QR10I
- CAS Number
- 79307-93-0
- Weight
- Average: 418.359
Monoisotopic: 417.137467851 - Chemical Formula
- C22H25Cl2N3O
- InChI Key
- YEJAJYAHJQIWNU-UHFFFAOYSA-N
- InChI
- InChI=1S/C22H24ClN3O.ClH/c1-25-13-4-5-18(12-14-25)26-22(27)20-7-3-2-6-19(20)21(24-26)15-16-8-10-17(23)11-9-16;/h2-3,6-11,18H,4-5,12-15H2,1H3;1H
- IUPAC Name
- 4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)-1,2-dihydrophthalazin-1-one hydrochloride
- SMILES
- Cl.CN1CCCC(CC1)N1N=C(CC2=CC=C(Cl)C=C2)C2=CC=CC=C2C1=O
- External Links
- PubChem Compound
- 54360
- ChemSpider
- 49103
- ChEBI
- 2951
- ChEMBL
- CHEMBL1200809
- Wikipedia
- Azelastine
- Predicted Properties
Property Value Source Water Solubility 0.0092 mg/mL ALOGPS logP 3.81 ALOGPS logP 4.04 Chemaxon logS -4.6 ALOGPS pKa (Strongest Basic) 8.88 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 35.91 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 110.52 m3·mol-1 Chemaxon Polarizability 42.04 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon