Guvacine hydrochlorideProduct ingredient for Guvacine

Name
Guvacine hydrochloride
Drug Entry
Guvacine

Guvacine is a pyridine alkaloid found in the Areca nut (also known as the Betel nut). It is an experimental drug with no approved indication. Experimental studies are still being investigated to determine all of the physiological effects and mechanisms of action of guvacine. Currently it has been determined that guvacine is a specific GABA reuptake inhibitor with no significant affinity at GABA receptors.

Accession Number
DBSALT000094
Structure
Thumb
Synonyms
Not Available
UNII
Not Available
CAS Number
Not Available
Weight
Average: 163.602
Monoisotopic: 163.040006276
Chemical Formula
C6H10ClNO2
InChI Key
FGNUNVVTHHKDAM-UHFFFAOYSA-N
InChI
InChI=1S/C6H9NO2.ClH/c8-6(9)5-2-1-3-7-4-5;/h2,7H,1,3-4H2,(H,8,9);1H
IUPAC Name
1,2,5,6-tetrahydropyridine-3-carboxylic acid hydrochloride
SMILES
Cl.OC(=O)C1=CCCNC1
External Links
PubChem Compound
11957555
ChemSpider
10131803
ChEBI
805348
ChEMBL
CHEMBL1256362
Predicted Properties
PropertyValueSource
Water Solubility30.8 mg/mLALOGPS
logP-2.2ALOGPS
logP-2.6ChemAxon
logS-0.62ALOGPS
pKa (Strongest Acidic)3.76ChemAxon
pKa (Strongest Basic)9.77ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area49.33 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity33.8 m3·mol-1ChemAxon
Polarizability12.84 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon