Cefalexin sodiumProduct ingredient for Cephalexin

Name
Cefalexin sodium
Drug Entry
Cephalexin

Cephalexin is the first of the first generation cephalosporins.7,8 This antibiotic contains a beta lactam and a dihydrothiazide.7 Cephalexin is used to treat a number of susceptible bacterial infections through inhibition of cell wall synthesis.9,Label Cephalexin was approved by the FDA on 4 January 1971.11

Accession Number
DBSALT000261
Structure
Thumb
Synonyms
Not Available
UNII
F78YJG0WXK
CAS Number
38932-40-0
Weight
Average: 369.371
Monoisotopic: 369.07592138
Chemical Formula
C16H16N3NaO4S
InChI Key
NZDYPHVJLWMLJI-UHFFFAOYSA-M
InChI
InChI=1S/C16H17N3O4S.Na/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9;/h2-6,10-11,15H,7,17H2,1H3,(H,18,20)(H,22,23);/q;+1/p-1
IUPAC Name
sodium (2R)-2-amino-N-[(6R,7R)-2-carboxy-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-7-yl]-2-phenylethanecarboximidate
SMILES
[Na+].[H][C@](N)(C([O-])=N[C@]1([H])C(=O)N2C(C(O)=O)=C(C)CS[C@]12[H])C1=CC=CC=C1
External Links
PubChem Compound
23667618
ChemSpider
3572169
ChEBI
59390
Predicted Properties
PropertyValueSource
Water Solubility0.179 mg/mLALOGPS
logP0.71ALOGPS
logP-1.5ChemAxon
logS-3.3ALOGPS
pKa (Strongest Acidic)3.66ChemAxon
pKa (Strongest Basic)8.63ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area119.05 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity100.05 m3·mol-1ChemAxon
Polarizability33.75 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon