Hydralazine hydrochlorideProduct ingredient for Hydralazine

Name
Hydralazine hydrochloride
Drug Entry
Hydralazine

Originally developed in the 1950s as a malaria treatment, hydralazine showed antihypertensive ability and was soon repurposed.15 Hydralazine is a hydrazine derivative vasodilator used alone or as adjunct therapy in the treatment of hypertension and only as adjunct therapy in the treatment of heart failure.10,18,19 Hydralazine is no longer a first line therapy for these indications since the development of newer antihypertensive medications.16

Hydralazine hydrochloride was FDA approved on 15 January 1953.17

Accession Number
DBSALT000792
Structure
Thumb
Synonyms
Hydralazine HCl
UNII
FD171B778Y
CAS Number
304-20-1
Weight
Average: 196.637
Monoisotopic: 196.051574015
Chemical Formula
C8H9ClN4
InChI Key
ZUXNZUWOTSUBMN-UHFFFAOYSA-N
InChI
InChI=1S/C8H8N4.ClH/c9-11-8-7-4-2-1-3-6(7)5-10-12-8;/h1-5H,9H2,(H,11,12);1H
IUPAC Name
1-hydrazinylidene-1,2-dihydrophthalazine hydrochloride
SMILES
Cl.NN=C1NN=CC2=CC=CC=C12
External Links
PubChem Compound
9351
ChemSpider
8985
ChEBI
31672
ChEMBL
CHEMBL542541
Wikipedia
Hydralazine
Predicted Properties
PropertyValueSource
Water Solubility1.59 mg/mLALOGPS
logP0.78ALOGPS
logP0.83ChemAxon
logS-2ALOGPS
pKa (Strongest Acidic)10.92ChemAxon
pKa (Strongest Basic)2.69ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area62.77 Å2ChemAxon
Rotatable Bond Count0ChemAxon
Refractivity59.33 m3·mol-1ChemAxon
Polarizability16.09 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon