Betamethasone sodium phosphateProduct ingredient for Betamethasone

Name
Betamethasone sodium phosphate
Drug Entry
Betamethasone

Betamethasone is a long-acting corticosteroid with immunosuppressive and antiinflammatory properties.11 It can be used topically to manage inflammatory skin conditions such as eczema, and parenterally to manage several disease states including autoimmune disorders.11 Betamethasone has potent glucocorticoid activity and negligible mineralocorticoid activity.11

Accession Number
DBSALT000850
Structure
Thumb
Synonyms
Not Available
UNII
7BK02SCL3W
CAS Number
151-73-5
Weight
Average: 516.41
Monoisotopic: 516.13012158
Chemical Formula
C22H28FNa2O8P
InChI Key
PLCQGRYPOISRTQ-LWCNAHDDSA-L
InChI
InChI=1S/C22H30FO8P.2Na/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30;;/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30);;/q;2*+1/p-2/t12-,15-,16-,17-,19-,20-,21-,22-;;/m0../s1
IUPAC Name
disodium (1R,2S,10S,11S,13S,14R,15S,17S)-1-fluoro-14,17-dihydroxy-2,13,15-trimethyl-14-[2-(phosphonatooxy)acetyl]tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-dien-5-one
SMILES
[Na+].[Na+].[H][C@]1(C)C[C@@]2([H])[C@]3([H])CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@]([H])(O)C[C@]2(C)[C@@]1(O)C(=O)COP([O-])([O-])=O
External Links
PubChem Compound
65478
ChemSpider
58930
ChEBI
3078
ChEMBL
CHEMBL1200762
Wikipedia
Betamethasone_sodium_phosphate
Predicted Properties
PropertyValueSource
Water Solubility1.52 mg/mLALOGPS
logP1.83ALOGPS
logP1.56ChemAxon
logS-2.5ALOGPS
pKa (Strongest Acidic)1.18ChemAxon
pKa (Strongest Basic)-3.4ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count7ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area147.02 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity111.12 m3·mol-1ChemAxon
Polarizability44.94 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon