Viomycin sulfateProduct ingredient for Viomycin

Name
Viomycin sulfate
Drug Entry
Viomycin

Viomycin is a tuberactinomycin antibiotic that was used to treat Mycobacterium tuberculosis until it was replaced by the less toxic capreomycin. These drugs bind RNA in bacterial ribosomes and inhibit protein synthesis. Viomycin was derived from the actinomycete Streptomyces puniceus

Accession Number
DBSALT000952
Structure
Thumb
Synonyms
Not Available
UNII
LKO141R05V
CAS Number
37883-00-4
Weight
Average: 783.77
Monoisotopic: 783.292964355
Chemical Formula
C25H45N13O14S
InChI Key
AQONYROJHRNYQQ-QMAPKBLTSA-N
InChI
InChI=1S/C25H43N13O10.H2O4S/c26-3-1-2-10(27)4-16(41)32-12-6-30-23(47)18(11-5-17(42)37-24(28)36-11)38-20(44)13(7-31-25(29)48)33-21(45)14(8-39)35-22(46)15(9-40)34-19(12)43;1-5(2,3)4/h7,10-12,14-15,17-18,39-40,42H,1-6,8-9,26-27H2,(H,30,47)(H,32,41)(H,33,45)(H,34,43)(H,35,46)(H,38,44)(H3,28,36,37)(H3,29,31,48);(H2,1,2,3,4)/b13-7-;/t10-,11+,12-,14-,15-,17-,18-;/m0./s1
IUPAC Name
(3S)-3,6-diamino-N-[(3S,6Z,9S,12S,15S)-3-[(4R,6S)-2-amino-6-hydroxy-1,4,5,6-tetrahydropyrimidin-4-yl]-6-[(carbamoylamino)methylidene]-9,12-bis(hydroxymethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentaazacyclohexadecan-15-yl]hexanamide; sulfuric acid
SMILES
OS(O)(=O)=O.NCCC[C@H](N)CC(=O)N[C@H]1CNC(=O)[C@@H](NC(=O)\C(NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC1=O)=C\NC(N)=O)[C@H]1C[C@H](O)NC(N)=N1
External Links
ChemSpider
4445631
ChEMBL
CHEMBL3989823
Wikipedia
Viomycin
Predicted Properties
PropertyValueSource
Water Solubility2.47 mg/mLALOGPS
logP-3.4ALOGPS
logP-11ChemAxon
logS-2.4ALOGPS
pKa (Strongest Acidic)10.38ChemAxon
pKa (Strongest Basic)9.96ChemAxon
Physiological Charge3ChemAxon
Hydrogen Acceptor Count15ChemAxon
Hydrogen Donor Count15ChemAxon
Polar Surface Area392.86 Å2ChemAxon
Rotatable Bond Count10ChemAxon
Refractivity161.16 m3·mol-1ChemAxon
Polarizability66.51 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability0ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon