Carbinoxamine maleateProduct ingredient for Carbinoxamine
- Name
- Carbinoxamine maleate
- Drug Entry
- Carbinoxamine
Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. The product label for carbinoxamine as an over the counter cough and cold medicine is being modified to state "do not use" in children under 4 years of age in order to prevent and reduce misuse, as many unapproved carbinoxamine-containing preparations contained inappropriate labeling, which promoted unapproved uses (including management of congestion, cough, the common cold, and the use in children under 2 years of age), which can potentially cause serious health risks.
- Accession Number
- DBSALT000963
- Structure
- Synonyms
- Not Available
- UNII
- 02O55696WH
- CAS Number
- 3505-38-2
- Weight
- Average: 406.86
Monoisotopic: 406.1295495 - Chemical Formula
- C20H23ClN2O5
- InChI Key
- GVNWHCVWDRNXAZ-BTJKTKAUSA-N
- InChI
- InChI=1S/C16H19ClN2O.C4H4O4/c1-19(2)11-12-20-16(15-5-3-4-10-18-15)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-10,16H,11-12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
- IUPAC Name
- (2Z)-but-2-enedioic acid; {2-[(4-chlorophenyl)(pyridin-2-yl)methoxy]ethyl}dimethylamine
- SMILES
- [H]\C(=C(/[H])C(O)=O)C(O)=O.CN(C)CCOC(C1=CC=C(Cl)C=C1)C1=CC=CC=N1
- External Links
- ChemSpider
- 4445564
- ChEBI
- 31353
- ChEMBL
- CHEMBL1200974
- Wikipedia
- Carbinoxamine
- Predicted Properties
Property Value Source Water Solubility 0.228 mg/mL ALOGPS logP 3.03 ALOGPS logP 3.27 Chemaxon logS -3.1 ALOGPS pKa (Strongest Basic) 8.87 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 25.36 Å2 Chemaxon Rotatable Bond Count 8 Chemaxon Refractivity 82.13 m3·mol-1 Chemaxon Polarizability 31.63 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon