Alfuzosin hydrochlorideProduct ingredient for Alfuzosin
- Name
- Alfuzosin hydrochloride
- Drug Entry
- Alfuzosin
Benign prostatic hyperplasia (BPH) refers to a benign growth or hyperplasia of the prostate and leads to lower urinary tract symptoms in men, such as urgency, frequency and changes to urine flow. The prevalence of BPH is as high as 50%-60% for males in their 60's, and this prevalence increases to 80%-90% of those over 70.6 Alfuzosin is an alpha-1 adrenergic blocker used in the symptomatic treatment of BPH that works by relaxing the muscles in the prostate and bladder neck.10 It was initially approved by the FDA in 2003 and is marketed by several pharmaceutical companies.9
- Accession Number
- DBSALT001063
- Structure
Structure for Alfuzosin hydrochloride (DBSALT001063)
- Synonyms
- Alfuzosin HCl
- UNII
- 75046A1XTN
- CAS Number
- 81403-68-1
- Weight
- Average: 425.91
Monoisotopic: 425.1829821 - Chemical Formula
- C19H28ClN5O4
- InChI Key
- YTNKWDJILNVLGX-UHFFFAOYSA-N
- InChI
- InChI=1S/C19H27N5O4.ClH/c1-24(8-5-7-21-18(25)14-6-4-9-28-14)19-22-13-11-16(27-3)15(26-2)10-12(13)17(20)23-19;/h10-11,14H,4-9H2,1-3H3,(H,21,25)(H2,20,22,23);1H
- IUPAC Name
- N-{3-[(4-imino-6,7-dimethoxy-3,4-dihydroquinazolin-2-yl)(methyl)amino]propyl}oxolane-2-carboximidic acid hydrochloride
- SMILES
- Cl.COC1=C(OC)C=C2C(=N)NC(=NC2=C1)N(C)CCCN=C(O)C1CCCO1
- External Links
- ChemSpider
- 64803
- ChEBI
- 32286
- ChEMBL
- CHEMBL1723
- Wikipedia
- Alfuzosin
- Predicted Properties
Property Value Source Water Solubility 0.146 mg/mL ALOGPS logP 1.37 ALOGPS logP -0.041 Chemaxon logS -3.4 ALOGPS pKa (Strongest Acidic) 2.26 Chemaxon pKa (Strongest Basic) 5.56 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 9 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 111.76 Å2 Chemaxon Rotatable Bond Count 8 Chemaxon Refractivity 118.18 m3·mol-1 Chemaxon Polarizability 42.21 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon