Mafenide AcetateProduct ingredient for Mafenide
- Name
- Mafenide Acetate
- Drug Entry
- Mafenide
Mafenide is a sulfonamide-type antimicrobial agent used to treat severe burns. It acts by reducing the bacterial population present in the burn tissue and promotes healing of deep burns.2 In 1998, mafenide acetate was approved under the FDA’s accelerated approval regulations. In November 2022, the use of mafenide acetate (powder for 5% topical solution) was withdrawn by the FDA due to an unresolved confirmatory study required to fulfill the accelerated approval requirements.3
- Accession Number
- DBSALT001076
- Structure
Structure for Mafenide Acetate (DBSALT001076)
- Synonyms
- Not Available
- UNII
- RQ6LP6Z0WY
- CAS Number
- 13009-99-9
- Weight
- Average: 246.28
Monoisotopic: 246.067428113 - Chemical Formula
- C9H14N2O4S
- InChI Key
- UILOTUUZKGTYFQ-UHFFFAOYSA-N
- InChI
- InChI=1S/C7H10N2O2S.C2H4O2/c8-5-6-1-3-7(4-2-6)12(9,10)11;1-2(3)4/h1-4H,5,8H2,(H2,9,10,11);1H3,(H,3,4)
- IUPAC Name
- 4-(aminomethyl)benzene-1-sulfonamide; acetic acid
- SMILES
- CC(O)=O.NCC1=CC=C(C=C1)S(N)(=O)=O
- External Links
- ChemSpider
- 23856
- ChEBI
- 31792
- ChEMBL
- CHEMBL1201161
- Predicted Properties
Property Value Source Water Solubility 5.18 mg/mL ALOGPS logP -0.37 ALOGPS logP -0.52 Chemaxon logS -1.6 ALOGPS pKa (Strongest Acidic) 10.25 Chemaxon pKa (Strongest Basic) 9.04 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 86.18 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 46.69 m3·mol-1 Chemaxon Polarizability 18.24 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon