Viloxazine hydrochlorideProduct ingredient for Viloxazine

Name
Viloxazine hydrochloride
Drug Entry
Viloxazine

Viloxazine is a selective norepinephrine reuptake inhibitor (NRI) that was used in some European countries as an antidepressant drug. It structurally differs from conventional tri- or tetra-cyclic antidepressants and it does not produce sedative anticholinergic or adrenergic effects in man 1. While displaying amphetamine-like CNS stimulant effects, there is little evidence of drug dependence from viloxazine therapy. Viloxazine hydrochloride is a common active ingredient in drug formulation. It was discovered and brought to market in 1976 by Imperial Chemical Industries and in early 2000's, it was withdrawn from the market.

Accession Number
DBSALT001262
Structure
Thumb
Synonyms
Viloxazine HCl
UNII
OQW30I1332
CAS Number
35604-67-2
Weight
Average: 273.76
Monoisotopic: 273.1131712
Chemical Formula
C13H20ClNO3
InChI Key
HJOCKFVCMLCPTP-UHFFFAOYSA-N
InChI
InChI=1S/C13H19NO3.ClH/c1-2-15-12-5-3-4-6-13(12)17-10-11-9-14-7-8-16-11;/h3-6,11,14H,2,7-10H2,1H3;1H
IUPAC Name
2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride
SMILES
Cl.CCOC1=CC=CC=C1OCC1CNCCO1
External Links
ChemSpider
64514
ChEMBL
CHEMBL2106483
Predicted Properties
PropertyValueSource
Water Solubility1.24 mg/mLALOGPS
logP1.71ALOGPS
logP1.49ChemAxon
logS-2.3ALOGPS
pKa (Strongest Basic)8.19ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area39.72 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity65.2 m3·mol-1ChemAxon
Polarizability26.2 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon