Pramoxine hydrochlorideProduct ingredient for Pramocaine
- Name
- Pramoxine hydrochloride
- Drug Entry
- Pramocaine
Pramocaine (also known as pramoxine or pramoxine HCI) is a topical anesthetic and antipruritic. It is used for many dermatological and anorectal/anogenital conditions including minor cuts/burns, insect bites, hives/rashes due to poison ivy exposure, hemorrhoids and other anorectal/anogenital disorders. Pramocaine is available by itself and in combination with other medications in various topical preparations. It works by preventing ionic fluctuations needed for neuron membrane depolarization and action potential propagation.
- Accession Number
- DBSALT001353
- Structure
Structure for Pramoxine hydrochloride (DBSALT001353)
- Synonyms
- Pramoxine HCl
- UNII
- 88AYB867L5
- CAS Number
- 637-58-1
- Weight
- Average: 329.87
Monoisotopic: 329.1757715 - Chemical Formula
- C17H28ClNO3
- InChI Key
- SYCBXBCPLUFJID-UHFFFAOYSA-N
- InChI
- InChI=1S/C17H27NO3.ClH/c1-2-3-12-20-16-5-7-17(8-6-16)21-13-4-9-18-10-14-19-15-11-18;/h5-8H,2-4,9-15H2,1H3;1H
- IUPAC Name
- 4-[3-(4-butoxyphenoxy)propyl]morpholine hydrochloride
- SMILES
- Cl.CCCCOC1=CC=C(OCCCN2CCOCC2)C=C1
- External Links
- ChemSpider
- 66586
- ChEBI
- 8358
- ChEMBL
- CHEMBL1201171
- Wikipedia
- Pramocaine
- Predicted Properties
Property Value Source Water Solubility 0.221 mg/mL ALOGPS logP 3.03 ALOGPS logP 2.84 Chemaxon logS -3.1 ALOGPS pKa (Strongest Basic) 7.06 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 30.93 Å2 Chemaxon Rotatable Bond Count 9 Chemaxon Refractivity 84.82 m3·mol-1 Chemaxon Polarizability 35.25 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon