Levobetaxolol hydrochlorideProduct ingredient for Levobetaxolol

Show full entry for Levobetaxolol
Name
Levobetaxolol hydrochloride
Drug Entry
Levobetaxolol

Levobetaxolol is a beta-blocker used to lower the pressure in the eye to treat conditions such as glaucoma. It was marketed as a 0.5% ophthalmic solution of levobetaxolol hydrochloride under the trade name Betaxon but has been discontinued.

See full entry for Levobetaxolol
Accession Number
DBSALT001395
Structure
Similar Structures
Synonyms
Levobetaxolol HCl
UNII
8MR4W4O06J
CAS Number
116209-55-3
Weight
Average: 343.89
Monoisotopic: 343.1914215
Chemical Formula
C18H30ClNO3
InChI Key
CHDPSNLJFOQTRK-LMOVPXPDSA-N
InChI
InChI=1S/C18H29NO3.ClH/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16;/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3;1H/t17-;/m0./s1
IUPAC Name
(2S)-1-{4-[2-(cyclopropylmethoxy)ethyl]phenoxy}-3-[(propan-2-yl)amino]propan-2-ol hydrochloride
SMILES
Cl.CC(C)NC[C@H](O)COC1=CC=C(CCOCC2CC2)C=C1
ChemSpider
54668
ChEBI
59256
ChEMBL
CHEMBL1200837
Wikipedia
Levobetaxolol
Predicted Properties
PropertyValueSource
Water Solubility0.0298 mg/mLALOGPS
logP3ALOGPS
logP2.54Chemaxon
logS-4ALOGPS
pKa (Strongest Acidic)14.09Chemaxon
pKa (Strongest Basic)9.67Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count4Chemaxon
Hydrogen Donor Count2Chemaxon
Polar Surface Area50.72 Å2Chemaxon
Rotatable Bond Count11Chemaxon
Refractivity88.64 m3·mol-1Chemaxon
Polarizability37.36 Å3Chemaxon
Number of Rings2Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon