Trimazosin hydrochlorideProduct ingredient for Trimazosin

Show full entry for Trimazosin
Name
Trimazosin hydrochloride
Drug Entry
Trimazosin

Trimazosin is a sympatholytic alpha blocker.

See full entry for Trimazosin
Accession Number
DBSALT001792
Structure
Similar Structures
Synonyms
Trimazosin HCl / Trimazosin hydrochloride monohydrate
UNII
827T79ILE7
CAS Number
53746-46-6
Weight
Average: 489.95
Monoisotopic: 489.1990261
Chemical Formula
C20H32ClN5O7
InChI Key
WXMXALSEIGHTOR-UHFFFAOYSA-N
InChI
InChI=1S/C20H29N5O6.ClH.H2O/c1-20(2,27)11-31-19(26)25-8-6-24(7-9-25)18-22-14-12(17(21)23-18)10-13(28-3)15(29-4)16(14)30-5;;/h10,27H,6-9,11H2,1-5H3,(H2,21,22,23);1H;1H2
IUPAC Name
2-hydroxy-2-methylpropyl 4-(4-imino-6,7,8-trimethoxy-3,4-dihydroquinazolin-2-yl)piperazine-1-carboxylate hydrate hydrochloride
SMILES
O.Cl.COC1=C(OC)C(OC)=C2N=C(NC(=N)C2=C1)N1CCN(CC1)C(=O)OCC(C)(C)O
ChemSpider
58287
ChEMBL
CHEMBL3989848
Predicted Properties
PropertyValueSource
Water Solubility0.154 mg/mLALOGPS
logP0.43ALOGPS
logP0.39Chemaxon
logS-3.4ALOGPS
pKa (Strongest Acidic)12.56Chemaxon
pKa (Strongest Basic)5.06Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count9Chemaxon
Hydrogen Donor Count3Chemaxon
Polar Surface Area128.94 Å2Chemaxon
Rotatable Bond Count7Chemaxon
Refractivity125.41 m3·mol-1Chemaxon
Polarizability46.24 Å3Chemaxon
Number of Rings3Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleYesChemaxon