Tropisetron MesylateProduct ingredient for Tropisetron
- Name
- Tropisetron Mesylate
- Drug Entry
- Tropisetron
Tropisetron is an indole derivative with antiemetic activity. As a selective serotonin receptor antagonist, tropisetron competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radiotherapy-induced nausea and vomiting.
Tropisetron appears to be well tolerated with the most frequently reported adverse effect being headache. Extrapyramidal side effects are rare upon using tropisetron.
- Accession Number
- DBSALT002052
- Structure
Structure for Tropisetron Mesylate (DBSALT002052)
- Synonyms
- Not Available
- UNII
- X2V6FDY03T
- CAS Number
- 833482-77-2
- Weight
- Average: 380.46
Monoisotopic: 380.140593055 - Chemical Formula
- C18H24N2O5S
- InChI Key
- FFTYLXTULVZQRZ-LUNMCBQDSA-N
- InChI
- InChI=1S/C17H20N2O2.CH4O3S/c1-19-11-6-7-12(19)9-13(8-11)21-17(20)15-10-18-16-5-3-2-4-14(15)16;1-5(2,3)4/h2-5,10-13,18H,6-9H2,1H3;1H3,(H,2,3,4)/t11-,12+,13+;
- IUPAC Name
- (1R,3S,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 1H-indole-3-carboxylate; methanesulfonic acid
- SMILES
- CS(O)(=O)=O.CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C1=CNC2=CC=CC=C12
- External Links
- ChemSpider
- 23254422
- Predicted Properties
Property Value Source Water Solubility 1.33 mg/mL ALOGPS logP 3.14 ALOGPS logP 2.63 Chemaxon logS -2.3 ALOGPS pKa (Strongest Acidic) 12.18 Chemaxon pKa (Strongest Basic) 9.34 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 45.33 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 81.5 m3·mol-1 Chemaxon Polarizability 31 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon