Pf 03758309 HydrochlorideProduct ingredient for PF-03758309
- Name
- Pf 03758309 Hydrochloride
- Drug Entry
- PF-03758309
PF-03758309 has been used in trials studying the treatment of Advanced Solid Tumors.
- Accession Number
- DBSALT002070
- Structure
Structure for Pf 03758309 Hydrochloride (DBSALT002070)
- Synonyms
- Not Available
- UNII
- BS52H27235
- CAS Number
- 1279034-84-2
- Weight
- Average: 527.09
Monoisotopic: 526.2030065 - Chemical Formula
- C25H31ClN8OS
- InChI Key
- DZSGSCZKFHGJNK-FSRHSHDFSA-N
- InChI
- InChI=1S/C25H30N8OS.ClH/c1-15-26-18-11-12-35-20(18)23(27-15)29-22-17-13-33(25(2,3)21(17)30-31-22)24(34)28-19(14-32(4)5)16-9-7-6-8-10-16;/h6-12,19H,13-14H2,1-5H3,(H,28,34)(H2,26,27,29,30,31);1H/t19-;/m1./s1
- IUPAC Name
- N-[(1S)-2-(dimethylamino)-1-phenylethyl]-6,6-dimethyl-3-({2-methylthieno[3,2-d]pyrimidin-4-yl}amino)-2H,4H,5H,6H-pyrrolo[3,4-c]pyrazole-5-carboxamide hydrochloride
- SMILES
- Cl.CN(C)C[C@@H](NC(=O)N1CC2=C(NC3=C4SC=CC4=NC(C)=N3)NN=C2C1(C)C)C1=CC=CC=C1
- External Links
- ChemSpider
- 32699223
- Predicted Properties
Property Value Source Water Solubility 0.00725 mg/mL ALOGPS logP 3.78 ALOGPS logP 3.72 Chemaxon logS -4.8 ALOGPS pKa (Strongest Acidic) 11.35 Chemaxon pKa (Strongest Basic) 8.11 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 6 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 102.07 Å2 Chemaxon Rotatable Bond Count 6 Chemaxon Refractivity 137.98 m3·mol-1 Chemaxon Polarizability 53.92 Å3 Chemaxon Number of Rings 5 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon