Tivozanib HydrochlorideProduct ingredient for Tivozanib

Name
Tivozanib Hydrochloride
Drug Entry
Tivozanib

Tivozanib has been used in trials studying the treatment and basic science of Solid Tumors, Glioblastoma, Ovarian Cancer, Prostate Cancer, and Stage IV Disease, among others.

Accession Number
DBSALT002078
Structure
Thumb
Synonyms
Not Available
UNII
8A9H4VK35Z
CAS Number
682745-41-1
Weight
Average: 509.34
Monoisotopic: 508.0916398
Chemical Formula
C22H22Cl2N4O6
InChI Key
RQXMKRRBJITKRN-UHFFFAOYSA-N
InChI
InChI=1S/C22H19ClN4O5.ClH.H2O/c1-12-8-21(27-32-12)26-22(28)25-16-5-4-13(9-15(16)23)31-18-6-7-24-17-11-20(30-3)19(29-2)10-14(17)18;;/h4-11H,1-3H3,(H2,25,26,27,28);1H;1H2
IUPAC Name
1-{2-chloro-4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-3-(5-methyl-1,2-oxazol-3-yl)urea hydrate hydrochloride
SMILES
O.Cl.COC1=CC2=NC=CC(OC3=CC=C(NC(=O)NC4=NOC(C)=C4)C(Cl)=C3)=C2C=C1OC
External Links
ChemSpider
9722757
ChEMBL
CHEMBL2105756
Predicted Properties
PropertyValueSource
Water Solubility0.0521 mg/mLALOGPS
logP4.25ALOGPS
logP4.22ChemAxon
logS-3.9ALOGPS
pKa (Strongest Acidic)10.36ChemAxon
pKa (Strongest Basic)5.89ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area107.74 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity120.85 m3·mol-1ChemAxon
Polarizability43.8 Å3ChemAxon
Number of Rings4ChemAxon
Bioavailability1ChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon