Relebactam sodiumProduct ingredient for Relebactam
- Name
- Relebactam sodium
- Drug Entry
- Relebactam
Relebactam is a diazabicyclooctane beta-lactamase inhibitor, similar in structure to avibactam.5,6 It includes a piperidine ring which reduces export from bacterial cells by producing a positive charge.6 It is currently available in a combination product which includes imipenem and cilastatin to treat complicated urinary tract infections (UTIs), pyelonephritis, and complicated intra-abdominal infections in adults.Label It is considered to be a last-line treatment option and gained FDA approval as part of the combination product RecarbrioⓇ in July 2019.9
- Accession Number
- DBSALT002185
- Structure
Structure for Relebactam sodium (DBSALT002185)
- Synonyms
- Not Available
- UNII
- EX0546AJ8R
- CAS Number
- 1502858-91-4
- Weight
- Average: 370.36
Monoisotopic: 370.0922998 - Chemical Formula
- C12H19N4NaO6S
- InChI Key
- MMUZXOWPDRLGBD-UXQCFNEQSA-M
- InChI
- InChI=1S/C12H20N4O6S.Na/c17-11(14-8-3-5-13-6-4-8)10-2-1-9-7-15(10)12(18)16(9)22-23(19,20)21;/h8-10,13H,1-7H2,(H,14,17)(H,19,20,21);/q;+1/p-1/t9-,10+;/m1./s1
- IUPAC Name
- sodium (1R,2S,5R)-7-oxo-2-[(piperidin-4-yl)carbamoyl]-1,6-diazabicyclo[3.2.1]octan-6-yl sulfate
- SMILES
- [Na+].[O-]S(=O)(=O)ON1[C@H]2C[N@]([C@@H](CC2)C(=O)NC2CCNCC2)C1=O
- External Links
- ChemSpider
- 34990358
- Predicted Properties
Property Value Source Water Solubility 6.94 mg/mL ALOGPS logP -1.1 ALOGPS logP -3.1 Chemaxon logS -1.7 ALOGPS pKa (Strongest Acidic) -2 Chemaxon pKa (Strongest Basic) 10.03 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 6 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 131.11 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 76.41 m3·mol-1 Chemaxon Polarizability 32.56 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon