Trandolapril hydrochlorideProduct ingredient for Trandolapril
- Name
- Trandolapril hydrochloride
- Drug Entry
- Trandolapril
Trandolapril is a non-sulhydryl prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is metabolized to its biologically active diacid form, trandolaprilat, in the liver. Trandolaprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Trandolapril may be used to treat mild to moderate hypertension, to improve survival following myocardial infarction in clinically stable patients with left ventricular dysfunction, as an adjunct treatment for congestive heart failure, and to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy.
- Accession Number
- DBSALT002307
- Structure
- Synonyms
- Not Available
- UNII
- 3EY8XK2J4T
- CAS Number
- 87725-72-2
- Weight
- Average: 467.0
Monoisotopic: 466.2234499 - Chemical Formula
- C24H35ClN2O5
- InChI Key
- QNSWMJYOGMUVGO-REWXTUPXSA-N
- InChI
- InChI=1S/C24H34N2O5.ClH/c1-3-31-24(30)19(14-13-17-9-5-4-6-10-17)25-16(2)22(27)26-20-12-8-7-11-18(20)15-21(26)23(28)29;/h4-6,9-10,16,18-21,25H,3,7-8,11-15H2,1-2H3,(H,28,29);1H/t16-,18+,19-,20-,21-;/m0./s1
- IUPAC Name
- (2S,3aR,7aS)-1-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-octahydro-1H-indole-2-carboxylic acid hydrochloride
- SMILES
- Cl.CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N1[C@H]2CCCC[C@@H]2C[C@H]1C(O)=O
- External Links
- ChemSpider
- 28528815
- Predicted Properties
Property Value Source Water Solubility 0.0207 mg/mL ALOGPS logP 1.31 ALOGPS logP 1.95 Chemaxon logS -4.3 ALOGPS pKa (Strongest Acidic) 3.8 Chemaxon pKa (Strongest Basic) 5.21 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 95.94 Å2 Chemaxon Rotatable Bond Count 10 Chemaxon Refractivity 115.79 m3·mol-1 Chemaxon Polarizability 47.09 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon