Olanzapine hydrochlorideProduct ingredient for Olanzapine
- Name
- Olanzapine hydrochloride
- Drug Entry
- Olanzapine
Olanzapine is a thienobenzodiazepine classified as an atypical or second-generation antipsychotic agent.2 The second-generation antipsychotics were introduced in the 90s and quickly gained traction due to their impressive efficacy, reduced risk for extrapyramidal side effects and reduced susceptibility to drug-drug interactions.5 Olanzapine very closely resembles clozapine and only differs by two additional methyl groups and the absence of a chloride moiety.10 It was discovered by scientists at Eli Lilly and approved to be marketed in the US in 1996.8
- Accession Number
- DBSALT002315
- Structure
Structure for Olanzapine hydrochloride (DBSALT002315)
- Synonyms
- Not Available
- UNII
- 0Q8K2L0MC3
- CAS Number
- 783334-36-1
- Weight
- Average: 348.89
Monoisotopic: 348.1175456 - Chemical Formula
- C17H21ClN4S
- InChI Key
- MFURKUWVJOJUHP-UHFFFAOYSA-N
- InChI
- InChI=1S/C17H20N4S.ClH/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12;/h3-6,11,19H,7-10H2,1-2H3;1H
- IUPAC Name
- 5-methyl-8-(4-methylpiperazin-1-yl)-4-thia-2,9-diazatricyclo[8.4.0.0^{3,7}]tetradeca-1(14),3(7),5,8,10,12-hexaene hydrochloride
- SMILES
- Cl.CN1CCN(CC1)C1=NC2=CC=CC=C2NC2=C1C=C(C)S2
- External Links
- ChemSpider
- 16133829
- Predicted Properties
Property Value Source Water Solubility 0.0942 mg/mL ALOGPS logP 3.61 ALOGPS logP 3.39 Chemaxon logS -3.5 ALOGPS pKa (Strongest Acidic) 13.17 Chemaxon pKa (Strongest Basic) 7.24 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 30.87 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 93.87 m3·mol-1 Chemaxon Polarizability 35.38 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon