Remoxipride hydrochlorideProduct ingredient for Remoxipride

Show full entry for Remoxipride
Name
Remoxipride hydrochloride
Drug Entry
Remoxipride

Remoxipride is an atypical antipsychotic agent that is specific for dopamine D2 receptors.1 It gained approval in the UK in 1989 but was withdrawn in 1993 after it was found to be associated with an increased incidence of aplastic anemia.1,5

See full entry for Remoxipride
Accession Number
DBSALT002343
Structure
Similar Structures
Synonyms
Not Available
UNII
MH4OU8RWCW
CAS Number
117591-79-4
Weight
Average: 425.75
Monoisotopic: 424.076448
Chemical Formula
C16H26BrClN2O4
InChI Key
SPFVHFBNXPARTR-IDMXKUIJSA-N
InChI
InChI=1S/C16H23BrN2O3.ClH.H2O/c1-4-19-9-5-6-11(19)10-18-16(20)14-13(21-2)8-7-12(17)15(14)22-3;;/h7-8,11H,4-6,9-10H2,1-3H3,(H,18,20);1H;1H2/t11-;;/m0../s1
IUPAC Name
3-bromo-N-{[(2S)-1-ethylpyrrolidin-2-yl]methyl}-2,6-dimethoxybenzamide hydrate hydrochloride
SMILES
O.Cl.CCN1CCC[C@H]1CNC(=O)C1=C(OC)C=CC(Br)=C1OC
ChemSpider
54687
ChEMBL
CHEMBL3989556
Predicted Properties
PropertyValueSource
Water Solubility0.127 mg/mLALOGPS
logP2.94ALOGPS
logP2.34Chemaxon
logS-3.5ALOGPS
pKa (Strongest Acidic)13.06Chemaxon
pKa (Strongest Basic)8.4Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count4Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area50.8 Å2Chemaxon
Rotatable Bond Count6Chemaxon
Refractivity90.56 m3·mol-1Chemaxon
Polarizability35.68 Å3Chemaxon
Number of Rings2Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon