Fostamatinib disodiumProduct ingredient for Fostamatinib

Name
Fostamatinib disodium
Drug Entry
Fostamatinib

Fostamatinib has been investigated for the treatment and basic science of Rheumatoid Arthritis and Immune Thrombocytopenic Purpura (ITP). It was approved on April 17, 2018, under the trade name Tavalisse for use in ITP 11,Label. Fostamatinib has also been granted orphan drug status by the FDA 11.

Recently, fostamatinib has been identified as a potential therapeutic for controlling acute respiratory distress syndrome (ARDS) in patients with severe COVID-19 through its ability to modulate the SYK kinase.8,9,10

Accession Number
DBSALT002691
Structure
Synonyms
Fostamatinib disodium / Fostamatinib disodium hexahydrate / Fostamatinib disodium salt hexahydrate
UNII
86EEZ49YVB
CAS Number
914295-16-2
Weight
Average: 732.52
Monoisotopic: 732.1755682
Chemical Formula
C23H36FN6Na2O15P
InChI Key
ZQGJCHHKJNSPMS-UHFFFAOYSA-L
InChI
InChI=1S/C23H26FN6O9P.2Na.6H2O/c1-23(2)21(31)30(11-38-40(32,33)34)20-14(39-23)6-7-17(28-20)27-19-13(24)10-25-22(29-19)26-12-8-15(35-3)18(37-5)16(9-12)36-4;;;;;;;;/h6-10H,11H2,1-5H3,(H2,32,33,34)(H2,25,26,27,28,29);;;6*1H2/q;2*+1;;;;;;/p-2
IUPAC Name
disodium hexahydrate [6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-3-oxo-2H,3H,4H-pyrido[3,2-b][1,4]oxazin-4-yl]methyl phosphate
SMILES
O.O.O.O.O.O.[Na+].[Na+].COC1=CC(NC2=NC=C(F)C(NC3=NC4=C(OC(C)(C)C(=O)N4COP([O-])([O-])=O)C=C3)=N2)=CC(OC)=C1OC
ChemSpider
30791400
ChEMBL
CHEMBL3989516
Wikipedia
Fostamatinib
Predicted Properties
PropertyValueSource
Water Solubility0.0596 mg/mLALOGPS
logP3.72ALOGPS
logP1.46Chemaxon
logS-4ALOGPS
pKa (Strongest Acidic)1.46Chemaxon
pKa (Strongest Basic)2.71Chemaxon
Physiological Charge-2Chemaxon
Hydrogen Acceptor Count13Chemaxon
Hydrogen Donor Count2Chemaxon
Polar Surface Area192.38 Å2Chemaxon
Rotatable Bond Count10Chemaxon
Refractivity134.85 m3·mol-1Chemaxon
Polarizability53.58 Å3Chemaxon
Number of Rings4Chemaxon
Bioavailability0Chemaxon
Rule of FiveNoChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleYesChemaxon