Encainide hydrochlorideProduct ingredient for Encainide
- Name
- Encainide hydrochloride
- Drug Entry
- Encainide
All drug products containing encainide hydrochloride. Encainide hydrochloride, formerly marketed as Enkaid capsules, was associated with increased death rates in patients who had asymptomatic heart rhythm abnormalities after a recent heart attack. The manufacturer of Enkaid capsules voluntarily withdrew the product from the US market on December 16, 1991.
- Accession Number
- DBSALT002712
- Structure
Structure for Encainide hydrochloride (DBSALT002712)
- Synonyms
- Encainide HCl
- External IDs
- MJ 9067-1 / MJ-9067 / MJ-9067-1
- UNII
- 4CH7J36N9S
- CAS Number
- 66794-74-9
- Weight
- Average: 388.94
Monoisotopic: 388.1917559 - Chemical Formula
- C22H29ClN2O2
- InChI Key
- OJIIZIWOLTYOBS-UHFFFAOYSA-N
- InChI
- InChI=1S/C22H28N2O2.ClH/c1-24-16-6-5-8-19(24)13-10-17-7-3-4-9-21(17)23-22(25)18-11-14-20(26-2)15-12-18;/h3-4,7,9,11-12,14-15,19H,5-6,8,10,13,16H2,1-2H3,(H,23,25);1H
- IUPAC Name
- 4-methoxy-N-{2-[2-(1-methylpiperidin-2-yl)ethyl]phenyl}benzamide hydrochloride
- SMILES
- Cl.COC1=CC=C(C=C1)C(=O)NC1=C(CCC2CCCCN2C)C=CC=C1
- External Links
- ChemSpider
- 43696
- ChEBI
- 59880
- ChEMBL
- CHEMBL2106155
- Predicted Properties
Property Value Source Water Solubility 0.00401 mg/mL ALOGPS logP 4.29 ALOGPS logP 4.49 Chemaxon logS -4.9 ALOGPS pKa (Strongest Acidic) 15.52 Chemaxon pKa (Strongest Basic) 9.48 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 41.57 Å2 Chemaxon Rotatable Bond Count 6 Chemaxon Refractivity 107.77 m3·mol-1 Chemaxon Polarizability 41.04 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon