Benzylpenicillin benzathine hydrateProduct ingredient for Benzylpenicillin

Name
Benzylpenicillin benzathine hydrate
Drug Entry
Benzylpenicillin

Benzylpenicillin (Penicillin G) is narrow spectrum antibiotic used to treat infections caused by susceptible bacteria. It is a natural penicillin antibiotic that is administered intravenously or intramuscularly due to poor oral absorption. Penicillin G may also be used in some cases as prophylaxis against susceptible organisms.

Natural penicillins are considered the drugs of choice for several infections caused by susceptible gram positive aerobic organisms, such as Streptococcus pneumoniae, groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridans group streptococci, and non-penicillinase producing staphylococcus. Aminoglycosides may be added for synergy against group B streptococcus (S. agalactiae), S. viridans, and Enterococcus faecalis. The natural penicillins may also be used as first or second line agents against susceptible gram positive aerobic bacilli such as Bacillus anthracis, Corynebacterium diphtheriae, and Erysipelothrix rhusiopathiae. Natural penicillins have limited activity against gram negative organisms; however, they may be used in some cases to treat infections caused by Neisseria meningitidis and Pasteurella. They are not generally used to treat anaerobic infections. Resistance patterns, susceptibility and treatment guidelines vary across regions.

Accession Number
DBSALT002768  (DB09323)
Structure
Thumb
Synonyms
Benzathine benzylpenicillin / Benzathine benzylpenicillin tetrahydrate / Benzathine penicillin / Benzathine penicillin G / Benzylpenicillin benzathine / Penicillin G benzathine
UNII
RIT82F58GK
CAS Number
41372-02-5
Weight
Average: 981.19
Monoisotopic: 980.402363873
Chemical Formula
C48H64N6O12S2
InChI Key
WIDKTXGNSOORHA-CJHXQPGBSA-N
InChI
InChI=1S/2C16H18N2O4S.C16H20N2.4H2O/c2*1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9;1-3-7-15(8-4-1)13-17-11-12-18-14-16-9-5-2-6-10-16;;;;/h2*3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);1-10,17-18H,11-14H2;4*1H2/t2*11-,12+,14-;;;;;/m11...../s1
IUPAC Name
SMILES
O.O.O.O.C(CNCC1=CC=CC=C1)NCC1=CC=CC=C1.[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)CC1=CC=CC=C1)C(O)=O.[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)CC1=CC=CC=C1)C(O)=O
External Links
PubChem Compound
25137901
PubChem Substance
310265205
ChemSpider
571100
ChEMBL
CHEMBL3989515
Wikipedia
Benzathine_benzylpenicillin
Predicted Properties
PropertyValueSource