Dapoxetine hydrochlorideProduct ingredient for Dapoxetine
- Name
- Dapoxetine hydrochloride
- Drug Entry
- Dapoxetine
Dapoxetine is a selective serotonin reuptake inhibitor, for the treatment of premature ejaculation. In a phase II proof-of-concept study conducted by PPD, dapoxetine demonstrated a statistically significant increase in ejaculatory latency when compared to placebo. Alza submitted a NDA to the FDA for dapoxetine for the treatment of premature ejaculation in December 2004. In October 2005, the company received a FDA Non-Approvable letter from the FDA, at which time they planned to work with regulators to address outstanding questions.
- Accession Number
- DBSALT002982
- Structure
Structure for Dapoxetine hydrochloride (DBSALT002982)
- Synonyms
- Dapoxetine HCl / Dapoxetine hydrochloride
- UNII
- U4OHT63MRI
- CAS Number
- 129938-20-1
- Weight
- Average: 341.88
Monoisotopic: 341.1546421 - Chemical Formula
- C21H24ClNO
- InChI Key
- IHWDIQRWYNMKFM-BDQAORGHSA-N
- InChI
- InChI=1S/C21H23NO.ClH/c1-22(2)20(18-10-4-3-5-11-18)15-16-23-21-14-8-12-17-9-6-7-13-19(17)21;/h3-14,20H,15-16H2,1-2H3;1H/t20-;/m0./s1
- IUPAC Name
- dimethyl[(1S)-3-(naphthalen-1-yloxy)-1-phenylpropyl]amine hydrochloride
- SMILES
- Cl.CN(C)[C@@H](CCOC1=CC=CC2=CC=CC=C12)C1=CC=CC=C1
- External Links
- ChemSpider
- 64452
- ChEMBL
- CHEMBL2106574
- Predicted Properties
Property Value Source Water Solubility 0.000837 mg/mL ALOGPS logP 4.75 ALOGPS logP 4.67 Chemaxon logS -5.6 ALOGPS pKa (Strongest Basic) 8.96 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 12.47 Å2 Chemaxon Rotatable Bond Count 6 Chemaxon Refractivity 96.14 m3·mol-1 Chemaxon Polarizability 35 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule Yes Chemaxon