Synephrine tartrateProduct ingredient for Synephrine
- Name
- Synephrine tartrate
- Drug Entry
- Synephrine
Synephrine, also referred to as, p-synephrine, is naturally occurring alkaloid. It is present in approved drug products as neo-synephrine, its m-substituted analog. p-synephrine and m-synephrine are known for their longer acting adrenergic effects compared to norepinephrine.
The similarity of naming between m-synephrine and the unsubstituted form, synephrine, is a source of some confusion however m-synephrine refers to a related drug more commonly known as phenylephrine. While the compounds share some chemical and pharmacological similarities, they are in fact distinct chemical entities.
- Accession Number
- DBSALT003093
- Structure
Structure for Synephrine tartrate (DBSALT003093)
- Synonyms
- Oxedrine hemitartrate / Oxedrine tartrate
- External IDs
- 240-647-8
- UNII
- 9I99I5995J
- CAS Number
- 16589-24-5
- Weight
- Average: 484.502
Monoisotopic: 484.205695238 - Chemical Formula
- C22H32N2O10
- InChI Key
- KZZBAIXGUQOHKI-CEAXSRTFSA-N
- InChI
- InChI=1S/2C9H13NO2.C4H6O6/c2*1-10-6-9(12)7-2-4-8(11)5-3-7;5-1(3(7)8)2(6)4(9)10/h2*2-5,9-12H,6H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t;;1-,2-/m..1/s1
- IUPAC Name
- (2R,3R)-2,3-dihydroxybutanedioic acid; bis(4-[1-hydroxy-2-(methylamino)ethyl]phenol)
- SMILES
- O[C@H]([C@@H](O)C(O)=O)C(O)=O.CNCC(O)C1=CC=C(O)C=C1.CNCC(O)C1=CC=C(O)C=C1
- External Links
- ChemSpider
- 91743
- Predicted Properties
Property Value Source Water Solubility 18.6 mg/mL ALOGPS logP -0.62 ALOGPS logP -0.071 Chemaxon logS -0.95 ALOGPS pKa (Strongest Acidic) 9.76 Chemaxon pKa (Strongest Basic) 9.15 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 52.49 Å2 Chemaxon Rotatable Bond Count 9 Chemaxon Refractivity 47.25 m3·mol-1 Chemaxon Polarizability 17.99 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon