Risperidone tartrateProduct ingredient for Risperidone
- Name
- Risperidone tartrate
- Drug Entry
- Risperidone
Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder.16 It is one of the most widely used SGAs. Paliperidone, another commonly used SGA, is the primary active metabolite of risperidone (i.e. 9-hydroxyrisperidone).16
Schizophrenia and various mood disorders are thought to be caused by an excess of dopaminergic D2 and serotonergic 5-HT2A activity, resulting in overactivity of central mesolimbic pathways and mesocortical pathways, respectively. Risperidone is thought to reduce this overactivity through inhibition of dopaminergic D2 receptors and serotonergic 5-HT2A receptors in the brain.16
Risperidone binds with a very high affinity to 5-HT2A receptors, approximately 10-20 fold greater than the drug's binding affinity to D2 receptors, and carries lesser activity at several off-targets which may responsible for some of its undesirable effects.16
- Accession Number
- DBSALT003205
- Structure
- Synonyms
- Not Available
- UNII
- 0S6B72E3LK
- CAS Number
- 666179-92-6
- Weight
- Average: 560.579
Monoisotopic: 560.228242202 - Chemical Formula
- C27H33FN4O8
- InChI Key
- KSWIOGDSXUFKOC-LREBCSMRSA-N
- InChI
- InChI=1S/C23H27FN4O2.C4H6O6/c1-15-18(23(29)28-10-3-2-4-21(28)25-15)9-13-27-11-7-16(8-12-27)22-19-6-5-17(24)14-20(19)30-26-22;5-1(3(7)8)2(6)4(9)10/h5-6,14,16H,2-4,7-13H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t;1-,2-/m.1/s1
- IUPAC Name
- (2R,3R)-2,3-dihydroxybutanedioic acid; 3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-4H,6H,7H,8H,9H-pyrido[1,2-a]pyrimidin-4-one
- SMILES
- O[C@H]([C@@H](O)C(O)=O)C(O)=O.CC1=C(CCN2CCC(CC2)C2=NOC3=C2C=CC(F)=C3)C(=O)N2CCCCC2=N1
- External Links
- ChemSpider
- 32697569
- Predicted Properties
Property Value Source Water Solubility 0.171 mg/mL ALOGPS logP 3.27 ALOGPS logP 2.63 Chemaxon logS -3.4 ALOGPS pKa (Strongest Basic) 8.76 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 61.94 Å2 Chemaxon Rotatable Bond Count 7 Chemaxon Refractivity 114.55 m3·mol-1 Chemaxon Polarizability 45.24 Å3 Chemaxon Number of Rings 5 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon