Trientine tetrahydrochlorideProduct ingredient for Triethylenetetramine
- Name
- Trientine tetrahydrochloride
- Drug Entry
- Triethylenetetramine
Triethylenetatramine (TETA), also known as trientine, is a potent and selective copper (II)-selective chelator. It is a structural analog of linear polyamine compounds, spermidine and spermine. TETA was first developed in Germany in 1861 and its chelating properties were first recognized in 1925.4 Initially approved by the FDA in 1985 as a second-line treatment for Wilson's disease,5 TETA is currently indicated to treat adults with stable Wilson’s disease who are de-coppered and tolerant to penicillamine.8
TETA has been investigated in clinical trials for the treatment of heart failure in patients with diabetes.2,3,4,5,6
- Accession Number
- DBSALT003345
- Structure
Structure for Trientine tetrahydrochloride (DBSALT003345)
- Synonyms
- Trientine 4HCl / Triethylenetetramine 4HCl / Triethylenetetramine tetrahydrochloride
- UNII
- 7360URE56Q
- CAS Number
- 4961-40-4
- Weight
- Average: 292.07
Monoisotopic: 290.0598575 - Chemical Formula
- C6H22Cl4N4
- InChI Key
- OKHMDSCYUWAQPT-UHFFFAOYSA-N
- InChI
- InChI=1S/C6H18N4.4ClH/c7-1-3-9-5-6-10-4-2-8;;;;/h9-10H,1-8H2;4*1H
- IUPAC Name
- (2-aminoethyl)({2-[(2-aminoethyl)amino]ethyl})amine tetrahydrochloride
- SMILES
- Cl.Cl.Cl.Cl.NCCNCCNCCN
- External Links
- ChemSpider
- 64522
- Wikipedia
- Triethylenetetramine
- Predicted Properties
Property Value Source logP -2.2 Chemaxon pKa (Strongest Basic) 9.77 Chemaxon Physiological Charge 2 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 4 Chemaxon Polar Surface Area 76.1 Å2 Chemaxon Rotatable Bond Count 7 Chemaxon Refractivity 43.32 m3·mol-1 Chemaxon Polarizability 18.05 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon